(S)-methyl 1-(4-bromo-2-methylphenylcarbamoyl)-3,3-dimethyl-2-methylenecyclohexanecarboxylate

Base Information

Chemical Name:(S)-methyl 1-(4-bromo-2-methylphenylcarbamoyl)-3,3-dimethyl-2-methylenecyclohexanecarboxylate
CAS No.:1610839-66-1
Molecular Formula:C₁₉H₂₄BrNO₃
Molecular Weight:394.308
Hs Code.:

Synonyms:(S)-methyl 1-(4-bromo-2-methylphenylcarbamoyl)-3,3-dimethyl-2-methylenecyclohexanecarboxylate

Suppliers and Price of (S)-methyl 1-(4-bromo-2-methylphenylcarbamoyl)-3,3-dimethyl-2-methylenecyclohexanecarboxylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-methyl 1-(4-bromo-2-methylphenylcarbamoyl)-3,3-dimethyl-2-methylenecyclohexanecarboxylate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (S)-methyl 1-(4-bromo-2-methylphenylcarbamoyl)-3,3-dimethyl-2-methylenecyclohexanecarboxylate

There total 10 articles about (S)-methyl 1-(4-bromo-2-methylphenylcarbamoyl)-3,3-dimethyl-2-methylenecyclohexanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₂H₁₇ClO₃

: 583-75-5
4-Bromo-2-methylaniline

: 1610839-66-1
(S)-methyl 1-(4-bromo-2-methylphenylcarbamoyl)-3,3-dimethyl-2-methylenecyclohexanecarboxylate

Guidance literature:: In dichloromethane; at 20 ℃;
DOI:10.1016/j.tetasy.2014.01.019

Reference yield:

: 104730-31-6
2-(4-hydroxy-1,1-dimethylbutyl)-1,3-dioxolane

: 1610839-66-1
(S)-methyl 1-(4-bromo-2-methylphenylcarbamoyl)-3,3-dimethyl-2-methylenecyclohexanecarboxylate

Guidance literature:: Multi-step reaction with 8 steps

1.1: triphenylphosphine; iodine; 1H-imidazole / dichloromethane / 2 h / 0 °C

2.1: toluene-4-sulfonic acid / water; acetone / 10 h / 50 °C

3.1: potassium carbonate / methanol / 12 h / 20 °C

4.1: sodium hydride / tetrahydrofuran / 0.08 h / 0 °C

4.2: 4 h / 0 - 50 °C

5.1: triethylamine; tin(IV) chloride / dichloromethane / 14 h / 20 °C

6.1: pig liver esterase; water / aq. phosphate buffer / 6 h / 30 °C / pH 8 / Enzymatic reaction

7.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 9 h / -78 °C

8.1: dichloromethane / 20 °C

With 1H-imidazole; pig liver esterase; oxalyl dichloride; water; iodine; tin(IV) chloride; sodium hydride; potassium carbonate; toluene-4-sulfonic acid; triethylamine; N,N-dimethyl-formamide; triphenylphosphine; In tetrahydrofuran; methanol; aq. phosphate buffer; dichloromethane; water; acetone;
DOI:10.1016/j.tetasy.2014.01.019

Reference yield:

: 147377-61-5
4-(1,3-dioxolan-2-yl)-1-iodo-4-methylpentane

: 1610839-66-1
(S)-methyl 1-(4-bromo-2-methylphenylcarbamoyl)-3,3-dimethyl-2-methylenecyclohexanecarboxylate

Guidance literature:: Multi-step reaction with 7 steps

1.1: toluene-4-sulfonic acid / water; acetone / 10 h / 50 °C

2.1: potassium carbonate / methanol / 12 h / 20 °C

3.1: sodium hydride / tetrahydrofuran / 0.08 h / 0 °C

3.2: 4 h / 0 - 50 °C

4.1: triethylamine; tin(IV) chloride / dichloromethane / 14 h / 20 °C

5.1: pig liver esterase; water / aq. phosphate buffer / 6 h / 30 °C / pH 8 / Enzymatic reaction

6.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 9 h / -78 °C

7.1: dichloromethane / 20 °C

With pig liver esterase; oxalyl dichloride; water; tin(IV) chloride; sodium hydride; potassium carbonate; toluene-4-sulfonic acid; triethylamine; N,N-dimethyl-formamide; In tetrahydrofuran; methanol; aq. phosphate buffer; dichloromethane; water; acetone;
DOI:10.1016/j.tetasy.2014.01.019