Butanoic acid, 3-[[(1,1-dimethylethoxy)carbonyl]amino]-2-methyl-, (2S,3S)-

Base Information

Chemical Name:Butanoic acid, 3-[[(1,1-dimethylethoxy)carbonyl]amino]-2-methyl-, (2S,3S)-
CAS No.:186494-09-7
Molecular Formula:C10H19 N O4
Molecular Weight:217.26216
Hs Code.:
Mol file:186494-09-7.mol

Synonyms:Butanoicacid, 3-[[(1,1-dimethylethoxy)carbonyl]amino]-2-methyl-, [S-(R*,R*)]-; (2S,3S)-3-[(tert-Butoxy)carbonyl]amino-2-methylbutanoicacid

Suppliers and Price of Butanoic acid, 3-[[(1,1-dimethylethoxy)carbonyl]amino]-2-methyl-, (2S,3S)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Total 1 raw suppliers

Chemical Property of Butanoic acid, 3-[[(1,1-dimethylethoxy)carbonyl]amino]-2-methyl-, (2S,3S)-

Chemical Property:

PSA：75.63000
LogP:2.01120

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Butanoic acid, 3-[[(1,1-dimethylethoxy)carbonyl]amino]-2-methyl-, (2S,3S)-

There total 5 articles about Butanoic acid, 3-[[(1,1-dimethylethoxy)carbonyl]amino]-2-methyl-, (2S,3S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 113806-44-3
Boc-[(S,S)-β^2,3-hAla]-CO2Me

: 186494-09-7
(2S,3S)-3-([(tert-butoxy)carbonyl]amino)-2-methylbutanoicacid

Guidance literature:: With sodium hydroxide; In methanol; for 36h;
DOI:10.1002/hlca.19960790802

Reference yield:

: 863115-39-3
trans-2-Benzyl-3,4-dimethylisoxazolidin-5-one

: 186494-09-7
(2S,3S)-3-([(tert-butoxy)carbonyl]amino)-2-methylbutanoicacid

Guidance literature:: Multi-step reaction with 2 steps

1: palladium on carbon; hydrogen / 1,4-dioxane

2: triethylamine

With palladium on carbon; hydrogen; triethylamine; In 1,4-dioxane;
DOI:10.1016/j.bmcl.2011.05.102

Reference yield:

: 158851-30-0
(S)-3-tert-butoxycarbonylaminobutyric acid

: 186494-09-7
(2S,3S)-3-([(tert-butoxy)carbonyl]amino)-2-methylbutanoicacid

Guidance literature:: Multi-step reaction with 3 steps

1.1: caesium carbonate / N,N-dimethyl-formamide / 7 h / 20 °C

2.1: lithium diisopropyl amide / tetrahydrofuran / 0.5 h / -78 °C

2.2: -78 - 20 °C

3.1: sodium hydroxide / water; ethanol / 2 h / 20 °C

With caesium carbonate; sodium hydroxide; lithium diisopropyl amide; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide;
DOI:10.1021/jacs.8b05162