[4-(2,2,2-Trifluoro-acetylamino)-phenyl]-acetic acid (2R,3R)-3-allyloxy-2-(2,2-dichloro-acetylamino)-3-(4-nitro-phenyl)-propyl ester

Base Information

Chemical Name:[4-(2,2,2-Trifluoro-acetylamino)-phenyl]-acetic acid (2R,3R)-3-allyloxy-2-(2,2-dichloro-acetylamino)-3-(4-nitro-phenyl)-propyl ester
CAS No.:165063-89-8
Molecular Formula:C₂₄H₂₂Cl₂F₃N₃O₇
Molecular Weight:592.356
Hs Code.:

Synonyms:[4-(2,2,2-Trifluoro-acetylamino)-phenyl]-acetic acid (2R,3R)-3-allyloxy-2-(2,2-dichloro-acetylamino)-3-(4-nitro-phenyl)-propyl ester

Suppliers and Price of [4-(2,2,2-Trifluoro-acetylamino)-phenyl]-acetic acid (2R,3R)-3-allyloxy-2-(2,2-dichloro-acetylamino)-3-(4-nitro-phenyl)-propyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of [4-(2,2,2-Trifluoro-acetylamino)-phenyl]-acetic acid (2R,3R)-3-allyloxy-2-(2,2-dichloro-acetylamino)-3-(4-nitro-phenyl)-propyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of [4-(2,2,2-Trifluoro-acetylamino)-phenyl]-acetic acid (2R,3R)-3-allyloxy-2-(2,2-dichloro-acetylamino)-3-(4-nitro-phenyl)-propyl ester

There total 4 articles about [4-(2,2,2-Trifluoro-acetylamino)-phenyl]-acetic acid (2R,3R)-3-allyloxy-2-(2,2-dichloro-acetylamino)-3-(4-nitro-phenyl)-propyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 105113-62-0
4-<(trifluoroacetyl)amino>benzeneacetic acid

: N-[(1R,2R)-2-Allyloxy-1-hydroxymethyl-2-(4-nitro-phenyl)-ethyl]-2,2-dichloro-acetamide

: 165063-89-8
[4-(2,2,2-Trifluoro-acetylamino)-phenyl]-acetic acid (2R,3R)-3-allyloxy-2-(2,2-dichloro-acetylamino)-3-(4-nitro-phenyl)-propyl ester

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; for 11h; Ambient temperature;
DOI:10.1021/ja00128a006

Reference yield:

: 56-75-7,85666-84-8
chloramphenicol

: 165063-89-8
[4-(2,2,2-Trifluoro-acetylamino)-phenyl]-acetic acid (2R,3R)-3-allyloxy-2-(2,2-dichloro-acetylamino)-3-(4-nitro-phenyl)-propyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 95 percent / imidazole / dimethylformamide / 19 h / Ambient temperature

2: 1.) NaH / 1.) DMF, RT, 10 min, 2.) DMF, a) 0 deg C, 1 h, b) RT, 10.5 h

3: 68 percent / aq. AcOH / tetrahydrofuran / 72 h / Ambient temperature

4: 100 percent / 1-(3-(dimethylamino)propyl)-3-ethylcarbodiimide hydrochloride, DMAP / CH₂Cl₂ / 11 h / Ambient temperature

With 1H-imidazole; dmap; sodium hydride; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ja00128a006

Reference yield:

: 864529-25-9
chloramphenicol

: 165063-89-8
[4-(2,2,2-Trifluoro-acetylamino)-phenyl]-acetic acid (2R,3R)-3-allyloxy-2-(2,2-dichloro-acetylamino)-3-(4-nitro-phenyl)-propyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) NaH / 1.) DMF, RT, 10 min, 2.) DMF, a) 0 deg C, 1 h, b) RT, 10.5 h

2: 68 percent / aq. AcOH / tetrahydrofuran / 72 h / Ambient temperature

3: 100 percent / 1-(3-(dimethylamino)propyl)-3-ethylcarbodiimide hydrochloride, DMAP / CH₂Cl₂ / 11 h / Ambient temperature

With dmap; sodium hydride; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ja00128a006