3-{6-(2-Methoxycarbonyl-ethyl)-5-[4-(4-methoxy-phenyl)-butoxy]-pyridin-2-ylmethylsulfanylmethyl}-benzoic acid methyl ester

Base Information

Chemical Name:3-{6-(2-Methoxycarbonyl-ethyl)-5-[4-(4-methoxy-phenyl)-butoxy]-pyridin-2-ylmethylsulfanylmethyl}-benzoic acid methyl ester
CAS No.:1027977-09-8
Molecular Formula:C₃₀H₃₅NO₆S
Molecular Weight:537.677
Hs Code.:

Synonyms:3-{6-(2-Methoxycarbonyl-ethyl)-5-[4-(4-methoxy-phenyl)-butoxy]-pyridin-2-ylmethylsulfanylmethyl}-benzoic acid methyl ester

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Chemical Property of 3-{6-(2-Methoxycarbonyl-ethyl)-5-[4-(4-methoxy-phenyl)-butoxy]-pyridin-2-ylmethylsulfanylmethyl}-benzoic acid methyl ester

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Technology Process of 3-{6-(2-Methoxycarbonyl-ethyl)-5-[4-(4-methoxy-phenyl)-butoxy]-pyridin-2-ylmethylsulfanylmethyl}-benzoic acid methyl ester

There total 13 articles about 3-{6-(2-Methoxycarbonyl-ethyl)-5-[4-(4-methoxy-phenyl)-butoxy]-pyridin-2-ylmethylsulfanylmethyl}-benzoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 42097-42-7
3-hydroxy-2-hydroxymethyl-6-methylpyridine

: 1027977-09-8
3-{6-(2-Methoxycarbonyl-ethyl)-5-[4-(4-methoxy-phenyl)-butoxy]-pyridin-2-ylmethylsulfanylmethyl}-benzoic acid methyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: MnO₂ / CH₂Cl₂ / 6 h / Ambient temperature

2: K₂CO₃ / dimethylformamide / 1.5 h / 90 °C

3: toluene / 1 h / 50 °C

4: 50percent m-chloroperoxybenzoic acid / CH₂Cl₂ / 15 h / Ambient temperature

5: trifluoroacetic anhydride / dimethylformamide / 18 h / Ambient temperature

6: H₂ / 5percent Pd-C / methanol / 5 h

7: SOCl₂ / toluene / 4 h / Ambient temperature

8: Cs₂CO₃ / dimethylformamide / 1.5 h / 60 °C

With manganese(IV) oxide; thionyl chloride; hydrogen; potassium carbonate; caesium carbonate; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic anhydride; palladium on activated charcoal; In methanol; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm00046a017

Reference yield:

: 66497-42-5
3-hydroxy-6-methylpicolinaldehyde

: 1027977-09-8
3-{6-(2-Methoxycarbonyl-ethyl)-5-[4-(4-methoxy-phenyl)-butoxy]-pyridin-2-ylmethylsulfanylmethyl}-benzoic acid methyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: K₂CO₃ / dimethylformamide / 1.5 h / 90 °C

2: toluene / 1 h / 50 °C

3: 50percent m-chloroperoxybenzoic acid / CH₂Cl₂ / 15 h / Ambient temperature

4: trifluoroacetic anhydride / dimethylformamide / 18 h / Ambient temperature

5: H₂ / 5percent Pd-C / methanol / 5 h

6: SOCl₂ / toluene / 4 h / Ambient temperature

7: Cs₂CO₃ / dimethylformamide / 1.5 h / 60 °C

With thionyl chloride; hydrogen; potassium carbonate; caesium carbonate; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic anhydride; palladium on activated charcoal; In methanol; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm00046a017

Reference yield:

: 52244-70-9,239474-80-7
4-(4-methoxyphenyl)butan-1-ol

: 1027977-09-8
3-{6-(2-Methoxycarbonyl-ethyl)-5-[4-(4-methoxy-phenyl)-butoxy]-pyridin-2-ylmethylsulfanylmethyl}-benzoic acid methyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: triphenylphosphine, imidazole, I₂ / toluene / 0.5 h / 65 °C

2: K₂CO₃ / dimethylformamide / 1.5 h / 90 °C

3: toluene / 1 h / 50 °C

4: 50percent m-chloroperoxybenzoic acid / CH₂Cl₂ / 15 h / Ambient temperature

5: trifluoroacetic anhydride / dimethylformamide / 18 h / Ambient temperature

6: H₂ / 5percent Pd-C / methanol / 5 h

7: SOCl₂ / toluene / 4 h / Ambient temperature

8: Cs₂CO₃ / dimethylformamide / 1.5 h / 60 °C

With 1H-imidazole; thionyl chloride; hydrogen; iodine; potassium carbonate; caesium carbonate; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; trifluoroacetic anhydride; palladium on activated charcoal; In methanol; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm00046a017