5-[3,5-bis(trifluoromethyl)benzyl]-7-(4-fluorophenyl)-9-(methylsulfonyl)-6-oxo-2,3,4,5-tetrahydro-6H-pyrimido[4,5-b][1,5]oxazocine

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Chemical Name:5-[3,5-bis(trifluoromethyl)benzyl]-7-(4-fluorophenyl)-9-(methylsulfonyl)-6-oxo-2,3,4,5-tetrahydro-6H-pyrimido[4,5-b][1,5]oxazocine
CAS No.:569684-14-6
Molecular Formula:C₂₄H₁₈F₇N₃O₄S
Molecular Weight:577.479
Hs Code.:

Synonyms:5-[3,5-bis(trifluoromethyl)benzyl]-7-(4-fluorophenyl)-9-(methylsulfonyl)-6-oxo-2,3,4,5-tetrahydro-6H-pyrimido[4,5-b][1,5]oxazocine

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Chemical Property of 5-[3,5-bis(trifluoromethyl)benzyl]-7-(4-fluorophenyl)-9-(methylsulfonyl)-6-oxo-2,3,4,5-tetrahydro-6H-pyrimido[4,5-b][1,5]oxazocine

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Technology Process of 5-[3,5-bis(trifluoromethyl)benzyl]-7-(4-fluorophenyl)-9-(methylsulfonyl)-6-oxo-2,3,4,5-tetrahydro-6H-pyrimido[4,5-b][1,5]oxazocine

There total 2 articles about 5-[3,5-bis(trifluoromethyl)benzyl]-7-(4-fluorophenyl)-9-(methylsulfonyl)-6-oxo-2,3,4,5-tetrahydro-6H-pyrimido[4,5-b][1,5]oxazocine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 183551-10-2
N-[3,5-bis (trifluoromethyl)-benzyl]-N-(3-hydroxypropyl)amine

: 569684-14-6
5-[3,5-bis(trifluoromethyl)benzyl]-7-(4-fluorophenyl)-9-(methylsulfonyl)-6-oxo-2,3,4,5-tetrahydro-6H-pyrimido[4,5-b][1,5]oxazocine

Guidance literature:: Multi-step reaction with 3 steps

1.1: thionyl chloride / DMF (N,N-dimethyl-formamide) / 2 h / Heating / reflux

1.2: 1 h / 0 °C

2.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water; toluene / 6 h / Heating / reflux

3.1: 3-chloro-benzenecarboperoxoic acid / tetrahydrofuran / 3 h / 20 °C

With thionyl chloride; sodium carbonate; 3-chloro-benzenecarboperoxoic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; DMF (N,N-dimethyl-formamide); water; toluene;

Reference yield:

: 569683-98-3
6-[3,5-bis(trifluoromethyl)benzyl]-4-chloro-2-methylthio-6,7,8,9-tetrahydro-5H-pyrimido[4,5-b][1,5]oxazocin-5-one

: 569684-14-6
5-[3,5-bis(trifluoromethyl)benzyl]-7-(4-fluorophenyl)-9-(methylsulfonyl)-6-oxo-2,3,4,5-tetrahydro-6H-pyrimido[4,5-b][1,5]oxazocine

Guidance literature:: Multi-step reaction with 2 steps

1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water; toluene / 6 h / Heating / reflux

2: 3-chloro-benzenecarboperoxoic acid / tetrahydrofuran / 3 h / 20 °C

With sodium carbonate; 3-chloro-benzenecarboperoxoic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; water; toluene;