4-[3,4-Dioxo-2-[1(R),2,2-trimethylpropylamino]-1-cyclobuten-1-ylamino]-3-ethylbenzonitrile

Base Information

Chemical Name:4-[3,4-Dioxo-2-[1(R),2,2-trimethylpropylamino]-1-cyclobuten-1-ylamino]-3-ethylbenzonitrile
CAS No.:177476-74-3
Molecular Formula:C₁₉H₂₃N₃O₂
Molecular Weight:325.411
Hs Code.:

Synonyms:(+)-(R)-4-[3,4-dioxo-2-(1,2,2-trimethyl-propylamino)-cyclobut-1-enylamino]-3-ethyl-benzonitrile

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Chemical Property of 4-[3,4-Dioxo-2-[1(R),2,2-trimethylpropylamino]-1-cyclobuten-1-ylamino]-3-ethylbenzonitrile

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Technology Process of 4-[3,4-Dioxo-2-[1(R),2,2-trimethylpropylamino]-1-cyclobuten-1-ylamino]-3-ethylbenzonitrile

There total 3 articles about 4-[3,4-Dioxo-2-[1(R),2,2-trimethylpropylamino]-1-cyclobuten-1-ylamino]-3-ethylbenzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 3850-30-4,22526-47-2,59367-75-8,66228-31-7
(R)-1,2,2-trimethylpropylamine

: 173668-38-7
4-(3,4-Dioxo-2-ethoxy-cyclobut-1-enylamino)-3-ethyl-benzonitrile

: 177476-74-3
(+)-(R)-4-[3,4-dioxo-2-(1,2,2-trimethyl-propylamino)-cyclobut-1-enylamino]-3-ethyl-benzonitrile

Guidance literature:: In ethanol; at 20 ℃; for 48h;
DOI:10.1021/jm9905099

Reference yield: 33.0%

: 3850-30-4,22526-47-2,59367-75-8,66228-31-7
(R)-1,2,2-trimethylpropylamine

: 5222-73-1
3,4-dimethoxy-3-cyclobutene-1,2-dione

: 170230-87-2
4'-amino-3'-ethylbenzonitrile

: 177476-74-3
(+)-(R)-4-[3,4-dioxo-2-(1,2,2-trimethyl-propylamino)-cyclobut-1-enylamino]-3-ethyl-benzonitrile

Guidance literature:: 3,4-dimethoxy-3-cyclobutene-1,2-dione; 4'-amino-3'-ethylbenzonitrile; In methanol; at 20 ℃; for 72h;

(R)-1,2,2-trimethylpropylamine; In methanol; for 48h;

Reference yield:

: 170230-87-2
4'-amino-3'-ethylbenzonitrile

: 177476-74-3
(+)-(R)-4-[3,4-dioxo-2-(1,2,2-trimethyl-propylamino)-cyclobut-1-enylamino]-3-ethyl-benzonitrile

Guidance literature:: Multi-step reaction with 2 steps

1.1: NaH / dimethylformamide / 1 h / 60 °C

1.2: 59 percent / dimethylformamide / 4 h / 80 °C

2.1: 73 percent / ethanol / 48 h / 20 °C

With sodium hydride; In ethanol; N,N-dimethyl-formamide; 1.1: Metallation / 1.2: Substitution / 2.1: Substitution;
DOI:10.1021/jm9905099