N-<(7-oxo-4,5,6,7-tetrahydrobenzothiophene-6-yl)acetyl>-4-(p-fluorobenzoyl)piperidine

Base Information

• Chemical Name: N-<(7-oxo-4,5,6,7-tetrahydrobenzothiophene-6-yl)acetyl>-4-(p-fluorobenzoyl)piperidine
• CAS No.: 240403-80-9
• Molecular Formula: C₂₂H₂₂FNO₃S
• Molecular Weight: 399.486

Synonyms:N-<(7-oxo-4,5,6,7-tetrahydrobenzothiophene-6-yl)acetyl>-4-(p-fluorobenzoyl)piperidine

Chemical Property of N-<(7-oxo-4,5,6,7-tetrahydrobenzothiophene-6-yl)acetyl>-4-(p-fluorobenzoyl)piperidine

Chemical Property:

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Technology Process of N-<(7-oxo-4,5,6,7-tetrahydrobenzothiophene-6-yl)acetyl>-4-(p-fluorobenzoyl)piperidine

There total 3 articles about N-<(7-oxo-4,5,6,7-tetrahydrobenzothiophene-6-yl)acetyl>-4-(p-fluorobenzoyl)piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

(4-fluorophenyl)-piperidin-4-ylmethanone (56346-57-7) + 2-(7-oxo-4,5,6,7-tetrahydrobenzo[b]thiophen-6-yl)acetic acid (240403-79-6) → N-<(7-oxo-4,5,6,7-tetrahydrobenzothiophene-6-yl)acetyl>-4-(p-fluorobenzoyl)piperidine (240403-80-9)

Guidance literature:

With bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; triethylamine; In dichloromethane; at 25 ℃; for 2h;

DOI:10.1021/jm981094e

Reference yield:

5,6-dihydro-4H-benzothiophen-7-one (1468-84-4) → N-<(7-oxo-4,5,6,7-tetrahydrobenzothiophene-6-yl)acetyl>-4-(p-fluorobenzoyl)piperidine (240403-80-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) LDA / 1.) -70 deg C

2: KOH / ethanol

3: 90 percent / BOP-Cl, Et₃N / CH₂Cl₂ / 2 h / 25 °C

With potassium hydroxide; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; triethylamine; lithium diisopropyl amide; In ethanol; dichloromethane;

DOI:10.1021/jm981094e

Reference yield:

(7-oxo-4,5,6,7-tetrahydro-benzo[b]thiophen-6-yl)-acetic acid ethyl ester → N-<(7-oxo-4,5,6,7-tetrahydrobenzothiophene-6-yl)acetyl>-4-(p-fluorobenzoyl)piperidine (240403-80-9)

Guidance literature:

Multi-step reaction with 2 steps

1: KOH / ethanol

2: 90 percent / BOP-Cl, Et₃N / CH₂Cl₂ / 2 h / 25 °C

With potassium hydroxide; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; triethylamine; In ethanol; dichloromethane;

DOI:10.1021/jm981094e

upstream raw materials:

(4-fluorophenyl)-piperidin-4-ylmethanone

2-(7-oxo-4,5,6,7-tetrahydrobenzo[b]thiophen-6-yl)acetic acid

5,6-dihydro-4H-benzothiophen-7-one

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