1-cyclopropyl-3-(4(S)-(5-methyl-4-((S)-3-methylmorpholino)-6,6-dioxido-5,7-dihydrothieno[3,4-d]pyrimidin-2-yl)phenyl)urea

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Chemical Name:1-cyclopropyl-3-(4(S)-(5-methyl-4-((S)-3-methylmorpholino)-6,6-dioxido-5,7-dihydrothieno[3,4-d]pyrimidin-2-yl)phenyl)urea
CAS No.:1429639-00-8
Molecular Formula:C₂₂H₂₇N₅O₄S
Molecular Weight:457.553
Hs Code.:

Synonyms:1-cyclopropyl-3-(4(S)-(5-methyl-4-((S)-3-methylmorpholino)-6,6-dioxido-5,7-dihydrothieno[3,4-d]pyrimidin-2-yl)phenyl)urea

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Chemical Property of 1-cyclopropyl-3-(4(S)-(5-methyl-4-((S)-3-methylmorpholino)-6,6-dioxido-5,7-dihydrothieno[3,4-d]pyrimidin-2-yl)phenyl)urea

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Technology Process of 1-cyclopropyl-3-(4(S)-(5-methyl-4-((S)-3-methylmorpholino)-6,6-dioxido-5,7-dihydrothieno[3,4-d]pyrimidin-2-yl)phenyl)urea

There total 9 articles about 1-cyclopropyl-3-(4(S)-(5-methyl-4-((S)-3-methylmorpholino)-6,6-dioxido-5,7-dihydrothieno[3,4-d]pyrimidin-2-yl)phenyl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 66319-05-9
2-<(2-Methoxycarbonyl)ethylthio>propionsaeure-ethylester

: 1429638-99-2
1-cyclopropyl-3-(4(R)-(5-methyl-4-((S)-3-methylmorpholino)-6,6-dioxido-5,7-dihydrothieno[3,4-d]pyrimidin-2-yl)phenyl)urea

: 1429639-00-8
1-cyclopropyl-3-(4(S)-(5-methyl-4-((S)-3-methylmorpholino)-6,6-dioxido-5,7-dihydrothieno[3,4-d]pyrimidin-2-yl)phenyl)urea

Guidance literature:: Multi-step reaction with 8 steps

1: sodium methylate / methanol / 3 h / 0 - 20 °C

2: sodium carbonate / water / 72 h / Darkness

3: water; hydrogenchloride; acetic acid / Reflux

4: P,P-dichlorophenylphosphine oxide / 6 h / 130 - 140 °C

5: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 20 °C

6: triethylamine / N,N-dimethyl-formamide

7: sodium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; 1,2-dimethoxyethane / 3 h / 80 °C / Inert atmosphere

8: ChiralPak AS-H / ethanol / 38 °C / 75007.5 Torr / Resolution of racemate

With P,P-dichlorophenylphosphine oxide; hydrogenchloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; water; sodium methylate; sodium carbonate; acetic acid; triethylamine; 3-chloro-benzenecarboperoxoic acid; In methanol; 1,2-dimethoxyethane; ethanol; dichloromethane; water; N,N-dimethyl-formamide; 7: |Suzuki Coupling;

Reference yield:

: 1-cyclopropyl-3-(4-(5-methyl-4-((S)-3-methylmorpholino)-6,6-dioxido-5,7-dihydrothieno[3,4-d]pyrimidin-2-yl)phenyl)urea

: 1429638-99-2
1-cyclopropyl-3-(4(R)-(5-methyl-4-((S)-3-methylmorpholino)-6,6-dioxido-5,7-dihydrothieno[3,4-d]pyrimidin-2-yl)phenyl)urea

: 1429639-00-8
1-cyclopropyl-3-(4(S)-(5-methyl-4-((S)-3-methylmorpholino)-6,6-dioxido-5,7-dihydrothieno[3,4-d]pyrimidin-2-yl)phenyl)urea

Guidance literature:: With ChiralPak AS-H; In ethanol; at 38 ℃; under 75007.5 Torr; Resolution of racemate;

Reference yield:

: 78648-41-6
3-(Methoxycarbonylmethylthio)-buttersaeuremethylester

: 1429638-99-2
1-cyclopropyl-3-(4(R)-(5-methyl-4-((S)-3-methylmorpholino)-6,6-dioxido-5,7-dihydrothieno[3,4-d]pyrimidin-2-yl)phenyl)urea

: 1429639-00-8
1-cyclopropyl-3-(4(S)-(5-methyl-4-((S)-3-methylmorpholino)-6,6-dioxido-5,7-dihydrothieno[3,4-d]pyrimidin-2-yl)phenyl)urea

Guidance literature:: Multi-step reaction with 8 steps

1: sodium methylate / toluene / Reflux

2: sodium carbonate / water / 72 h / Darkness

3: water; hydrogenchloride; acetic acid / Reflux

4: P,P-dichlorophenylphosphine oxide / 6 h / 130 - 140 °C

5: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 20 °C

6: triethylamine / N,N-dimethyl-formamide

7: sodium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; 1,2-dimethoxyethane / 3 h / 80 °C / Inert atmosphere

8: ChiralPak AS-H / ethanol / 38 °C / 75007.5 Torr / Resolution of racemate

With P,P-dichlorophenylphosphine oxide; hydrogenchloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; water; sodium methylate; sodium carbonate; acetic acid; triethylamine; 3-chloro-benzenecarboperoxoic acid; In 1,2-dimethoxyethane; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; 7: |Suzuki Coupling;