3,4-dichloro-N-hydroxybenzimidoyl chloride

Base Information

• Chemical Name: 3,4-dichloro-N-hydroxybenzimidoyl chloride
• CAS No.: 58933-36-1
• Molecular Formula: C₇H₄Cl₃NO
• Molecular Weight: 224.474
• Mol file: 58933-36-1.mol

Synonyms:3,4-dichloro-N-hydroxybenzimidoyl chloride

Chemical Property of 3,4-dichloro-N-hydroxybenzimidoyl chloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3,4-dichloro-N-hydroxybenzimidoyl chloride

There total 2 articles about 3,4-dichloro-N-hydroxybenzimidoyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3,4-dichlorobenzaldehyde (6287-38-3) → 3,4-dichloro-N-hydroxybenzimidoyl chloride (58933-36-1)

Guidance literature:

Multi-step reaction with 2 steps

1: aq. NH₂OH*HCl; AcONa / ethanol / 12 h

2: N-chlorosuccinimide; pyridine / CHCl₃; tetrahydrofuran / 2 h

With pyridine; N-chloro-succinimide; hydroxylamine hydrochloride; sodium acetate; In tetrahydrofuran; ethanol; chloroform;

DOI:10.1016/S0960-894X(03)00130-6

Reference yield:

→ 3,4-dichloro-N-hydroxybenzimidoyl chloride (58933-36-1)

Guidance literature:

/BRN= 206792/, Cl2;

Reference yield: 82.0%

3,4-dichloro-N-hydroxybenzimidoyl chloride (58933-36-1) + 4-trifluoromethylphenylacetylene (705-31-7) → 3-(3,4-dichlorophenyl)-5-{4-(trifluoromethyl)phenyl}isoxazole

Guidance literature:

With triethylamine; In dichloromethane; at 40 ℃; for 0.5h; Inert atmosphere;

DOI:10.1021/acs.orglett.0c00910

upstream raw materials:

3,4-dichlorobenzaldehyde

Downstream raw materials:

3-(3,4-dichloro-phenyl)-isoxazole-4,5-dicarboxylic acid dimethyl ester

4-(3,4-dichloro-phenyl)-3-(4-nitro-phenyl)-3H-[1,2,3,5]oxathiadiazole 2-oxide

O-(Z-Phenylalanyl)-3,4-dichlor-benzohydroxamsaeure

m,p-dichlorobenzonitrile N-oxide

Refernces

• 1、 Radhika,Saisree,Harinadha, Babu V.. "Design, docking and synthesis of novel bromo isatin incorporated isoxazole derivatives as vegfr-2 inhibitors". . p. 1 - 7. Retrieved 2019/05/17.
• 2、 Xie, Fei,Ni, Tingjunhong,Zhao, Jing,Pang, Lei,Li, Ran,Cai, Zhan,Ding, Zichao,Wang, Ting,Yu, Shichong,Jin, Yongsheng,Zhang, Dazhi,Jiang, Yuanying. "Design, synthesis, and in vitro evaluation of novel antifungal triazoles". . p. 2171 - 2173. Retrieved 2017/04/28.