N-(2-amino-2-oxoethyl)-3-(hydroxymethyl)-5-methyl-1-[2-[3-(trifluoromethyl)benzyl]-1-benzothiophen-7-yl]-1H-pyrazole-4-carboxamide

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Chemical Name:N-(2-amino-2-oxoethyl)-3-(hydroxymethyl)-5-methyl-1-[2-[3-(trifluoromethyl)benzyl]-1-benzothiophen-7-yl]-1H-pyrazole-4-carboxamide
CAS No.:1313197-47-5
Molecular Formula:C₂₄H₂₁F₃N₄O₃S
Molecular Weight:502.517
Hs Code.:

Synonyms:N-(2-amino-2-oxoethyl)-3-(hydroxymethyl)-5-methyl-1-[2-[3-(trifluoromethyl)benzyl]-1-benzothiophen-7-yl]-1H-pyrazole-4-carboxamide

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Chemical Property of N-(2-amino-2-oxoethyl)-3-(hydroxymethyl)-5-methyl-1-[2-[3-(trifluoromethyl)benzyl]-1-benzothiophen-7-yl]-1H-pyrazole-4-carboxamide

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Technology Process of N-(2-amino-2-oxoethyl)-3-(hydroxymethyl)-5-methyl-1-[2-[3-(trifluoromethyl)benzyl]-1-benzothiophen-7-yl]-1H-pyrazole-4-carboxamide

There total 4 articles about N-(2-amino-2-oxoethyl)-3-(hydroxymethyl)-5-methyl-1-[2-[3-(trifluoromethyl)benzyl]-1-benzothiophen-7-yl]-1H-pyrazole-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₈H₂₉F₃N₄O₃S

: 1313197-47-5
N-(2-amino-2-oxoethyl)-3-(hydroxymethyl)-5-methyl-1-[2-[3-(trifluoromethyl)benzyl]-1-benzothiophen-7-yl]-1H-pyrazole-4-carboxamide

Guidance literature:: With hydrogenchloride; In ethyl acetate; at 10 - 35 ℃;

Reference yield:

: 1207970-76-0
4,4,5,5-tetramethyl-2-(2-(3-(trifluoromethyl)benzyl)-1-benzothiophen-7-yl)-1,3,2-dioxaborolane

: 1313197-47-5
N-(2-amino-2-oxoethyl)-3-(hydroxymethyl)-5-methyl-1-[2-[3-(trifluoromethyl)benzyl]-1-benzothiophen-7-yl]-1H-pyrazole-4-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: pyridine / copper(II) acetate monohydrate / 55 °C

2: sodium hydroxide; water / ethanol; tetrahydrofuran / 6 h / 85 °C

3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 0.08 h / 10 - 35 °C

4: hydrogenchloride / ethyl acetate / 10 - 35 °C

With pyridine; hydrogenchloride; water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; copper(II) acetate monohydrate; In tetrahydrofuran; ethanol; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 518990-61-9
ethyl 5-(tert-butoxymethyl)-3-methyl-1H-pyrazole-4-carboxylate

: 1313197-47-5
N-(2-amino-2-oxoethyl)-3-(hydroxymethyl)-5-methyl-1-[2-[3-(trifluoromethyl)benzyl]-1-benzothiophen-7-yl]-1H-pyrazole-4-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: pyridine / copper(II) acetate monohydrate / 55 °C

2: sodium hydroxide; water / ethanol; tetrahydrofuran / 6 h / 85 °C

3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 0.08 h / 10 - 35 °C

4: hydrogenchloride / ethyl acetate / 10 - 35 °C

With pyridine; hydrogenchloride; water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; copper(II) acetate monohydrate; In tetrahydrofuran; ethanol; ethyl acetate; N,N-dimethyl-formamide;