3-(2-Chloro-ethyl)-4-oxo-3,4-dihydro-imidazo[5,1-d][1,2,3,5]tetrazine-8-carboxylic acid benzyloxy-amide

Base Information

Chemical Name:3-(2-Chloro-ethyl)-4-oxo-3,4-dihydro-imidazo[5,1-d][1,2,3,5]tetrazine-8-carboxylic acid benzyloxy-amide
CAS No.:113942-34-0
Molecular Formula:C₁₄H₁₃ClN₆O₃
Molecular Weight:348.749
Hs Code.:

Synonyms:3-(2-Chloro-ethyl)-4-oxo-3,4-dihydro-imidazo[5,1-d][1,2,3,5]tetrazine-8-carboxylic acid benzyloxy-amide

Suppliers and Price of 3-(2-Chloro-ethyl)-4-oxo-3,4-dihydro-imidazo[5,1-d][1,2,3,5]tetrazine-8-carboxylic acid benzyloxy-amide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 3-(2-Chloro-ethyl)-4-oxo-3,4-dihydro-imidazo[5,1-d][1,2,3,5]tetrazine-8-carboxylic acid benzyloxy-amide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 3-(2-Chloro-ethyl)-4-oxo-3,4-dihydro-imidazo[5,1-d][1,2,3,5]tetrazine-8-carboxylic acid benzyloxy-amide

There total 3 articles about 3-(2-Chloro-ethyl)-4-oxo-3,4-dihydro-imidazo[5,1-d][1,2,3,5]tetrazine-8-carboxylic acid benzyloxy-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 113942-31-7
benzyl 3-(2-chloroethyl)-3H-4-oxoimidazo<5,1-d>-1,2,3,5-tetrazine-8-carboxylate

: 113942-34-0
3-(2-Chloro-ethyl)-4-oxo-3,4-dihydro-imidazo[5,1-d][1,2,3,5]tetrazine-8-carboxylic acid benzyloxy-amide

Guidance literature:: Multi-step reaction with 3 steps

1: 54 percent / H₂ / palladium on charcoal (10percent)

2: 99 percent / thionyl chloride, N,N-dimethylformamide / 2.5 h / Heating

3: 20 percent / tetrahydrofuran; H₂O / 0.5 h

With thionyl chloride; hydrogen; N,N-dimethyl-formamide; palladium on activated charcoal; In tetrahydrofuran; water;
DOI:10.1021/jm00167a018

Reference yield:

: 85622-95-3
mitozolomide

: 113942-34-0
3-(2-Chloro-ethyl)-4-oxo-3,4-dihydro-imidazo[5,1-d][1,2,3,5]tetrazine-8-carboxylic acid benzyloxy-amide

Guidance literature:: Multi-step reaction with 3 steps

1: 77 percent / concd. sulfuric acid, sodium nitrite / H₂O / 2.5 h / 35 °C

2: 99 percent / thionyl chloride, N,N-dimethylformamide / 2.5 h / Heating

3: 20 percent / tetrahydrofuran; H₂O / 0.5 h

With thionyl chloride; sulfuric acid; N,N-dimethyl-formamide; sodium nitrite; In tetrahydrofuran; water;
DOI:10.1021/jm00167a018

Reference yield:

: 113942-32-8
3-(2-chloroethyl)-3,4-dihydro-4-oxoimidazo<5,1-d><1,2,3,5>tetrazine-8-carboxylic acid

: 113942-34-0
3-(2-Chloro-ethyl)-4-oxo-3,4-dihydro-imidazo[5,1-d][1,2,3,5]tetrazine-8-carboxylic acid benzyloxy-amide

Guidance literature:: Multi-step reaction with 2 steps

1: 99 percent / thionyl chloride, N,N-dimethylformamide / 2.5 h / Heating

2: 20 percent / tetrahydrofuran; H₂O / 0.5 h

With thionyl chloride; N,N-dimethyl-formamide; In tetrahydrofuran; water;
DOI:10.1021/jm00167a018