(3S,4R)-3-((2,2-d2-benzo[d][1,3]dioxol-5-yloxy)methyl-d2)-4-(4-fluorophenyl)-1-methylpiperidine

Base Information

Chemical Name:(3S,4R)-3-((2,2-d2-benzo[d][1,3]dioxol-5-yloxy)methyl-d2)-4-(4-fluorophenyl)-1-methylpiperidine
CAS No.:1005412-32-7
Molecular Formula:C₂₀H₂₂FNO₃
Molecular Weight:347.366
Hs Code.:

Synonyms:(3S,4R)-3-((2,2-d2-benzo[d][1,3]dioxol-5-yloxy)methyl-d2)-4-(4-fluorophenyl)-1-methylpiperidine

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Chemical Property of (3S,4R)-3-((2,2-d2-benzo[d][1,3]dioxol-5-yloxy)methyl-d2)-4-(4-fluorophenyl)-1-methylpiperidine

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Technology Process of (3S,4R)-3-((2,2-d2-benzo[d][1,3]dioxol-5-yloxy)methyl-d2)-4-(4-fluorophenyl)-1-methylpiperidine

There total 4 articles about (3S,4R)-3-((2,2-d2-benzo[d][1,3]dioxol-5-yloxy)methyl-d2)-4-(4-fluorophenyl)-1-methylpiperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 923932-05-2
benzo[d][1,3]dioxol-(2,2-d2)-5-ol

: 1131450-89-9
C₁₉H₂₀⁽²⁾H₂FNO₃S

: 1005412-32-7
(3S,4R)-3-((2,2-d2-benzo[d][1,3]dioxol-5-yloxy)methyl-d2)-4-(4-fluorophenyl)-1-methylpiperidine

Guidance literature:: With sodium methylate; In water; N,N-dimethyl-formamide; at 50 - 70 ℃; for 1.58333h;

Reference yield:

: 710336-81-5
dideuterocatechol

: 1005412-32-7
(3S,4R)-3-((2,2-d2-benzo[d][1,3]dioxol-5-yloxy)methyl-d2)-4-(4-fluorophenyl)-1-methylpiperidine

Guidance literature:: Multi-step reaction with 3 steps

1.1: water-d2; potassium carbonate / 1-methyl-pyrrolidin-2-one / 2.5 h / 110 °C

2.1: formic acid; dihydrogen peroxide / dichloromethane; water / 21.25 h / 15.2 - 30 °C / Heating / reflux

2.2: 0.5 - 1 h / 0 - 20 °C

2.3: pH 3

3.1: sodium methylate / water; N,N-dimethyl-formamide / 1.58 h / 50 - 70 °C

With formic acid; dihydrogen peroxide; water-d2; sodium methylate; potassium carbonate; In 1-methyl-pyrrolidin-2-one; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 946119-86-4
((3S,4R)-4-(-4-fluorophenyl)-1-methylpiperidin-3-yl)methanol-d2

: 1005412-32-7
(3S,4R)-3-((2,2-d2-benzo[d][1,3]dioxol-5-yloxy)methyl-d2)-4-(4-fluorophenyl)-1-methylpiperidine

Guidance literature:: Multi-step reaction with 2 steps

1: N,N-dimethyl-ethanamine / toluene / 1.5 h / 0 - 10 °C

2: sodium methylate / water; N,N-dimethyl-formamide / 1.58 h / 50 - 70 °C

With N,N-dimethyl-ethanamine; sodium methylate; In water; N,N-dimethyl-formamide; toluene;