(6-BENZHYDRYLOXYCARBONYLAMINO-PURIN-9-YL)-ACETIC ACID

Base Information

• Chemical Name: (6-BENZHYDRYLOXYCARBONYLAMINO-PURIN-9-YL)-ACETIC ACID
• CAS No.: 186046-80-0
• Molecular Formula: C21H17 N5 O4
• Molecular Weight: 403.397
• Hs Code.: 2933990090
• Mol file: 186046-80-0.mol

Synonyms:(6-BENZHYDRYLOXYCARBONYLAMINO-PURIN-9-YL)-ACETIC ACID ;(6-Benzhydryloxycarbonylamino-purin-9-yl)-acetic

Chemical Property of (6-BENZHYDRYLOXYCARBONYLAMINO-PURIN-9-YL)-ACETIC ACID

Chemical Property:

• Refractive Index: 1.695
• Boiling Point: °Cat760mmHg
• PKA: 3.50±0.10(Predicted)
• Flash Point: °C
• PSA: 119.23000
• Density: 1.41g/cm³
• LogP: 3.32200
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

2-(6-(((Benzhydryloxy)carbonyl)amino)-9H-purin-9-yl)acetic acid 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (6-BENZHYDRYLOXYCARBONYLAMINO-PURIN-9-YL)-ACETIC ACID

There total 3 articles about (6-BENZHYDRYLOXYCARBONYLAMINO-PURIN-9-YL)-ACETIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(6-benzhydryloxycarbonylamino-purin-9-yl)-acetic acid benzyl ester (1052676-79-5) → [6-N-(benzhydryloxycarbonyl)adenin-9-yl]acetic acid (186046-80-0)

Guidance literature:

With lithium hydroxide; water; In ethanol; acetonitrile; at 10 ℃;

DOI:10.1021/ol0358408

Reference yield:

adenine (66224-66-6,66224-67-7,66224-68-8,66224-69-9,134434-48-3,134434-49-4,134454-76-5,134461-75-9) → [6-N-(benzhydryloxycarbonyl)adenin-9-yl]acetic acid (186046-80-0)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium hydride / dimethylformamide / 3 h

1.2: 72 percent / dimethylformamide / 12 h / 0 - 20 °C

2.1: dimethylformamide / 2 h / 105 °C

2.2: dimethylformamide

3.1: 30.5 g / LiOH*H₂O; H₂O / acetonitrile; ethanol / 10 °C

With lithium hydroxide; water; sodium hydride; In ethanol; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1021/ol0358408

Reference yield:

benzyl 2-(6-amino-9H-purin-9-yl)acetate (183181-27-3) → [6-N-(benzhydryloxycarbonyl)adenin-9-yl]acetic acid (186046-80-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: dimethylformamide / 2 h / 105 °C

1.2: dimethylformamide

2.1: 30.5 g / LiOH*H₂O; H₂O / acetonitrile; ethanol / 10 °C

With lithium hydroxide; water; In ethanol; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1021/ol0358408

upstream raw materials:

(6-benzhydryloxycarbonylamino-purin-9-yl)-acetic acid benzyl ester

adenine

benzyl 2-(6-amino-9H-purin-9-yl)acetate

Downstream raw materials:

N-[2-(benzothiazole-2-sulfonylamino)-ethyl]-N-{[6-N-(benzhydryloxycarbonyl)-adenin-9-yl]-acetyl}-glycine ethyl ester

benzyl N-(2-azidoethyl)-N-[6-N-(benzhydryloxycarbonyl)adenine-9-acetyl]glycinate

N^γ-Fmoc-N^α-[N⁶-(benzhydryloxycarbonyl)-(adenin-9-yl)acetyl]-2,4-diaminobutyric acid

Refernces