1,3-bis[(1-(ethylcarboxymethyl)-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-3-yl)methyl]-2-acetoxy-5-methylbenzene

Base Information

• Chemical Name: 1,3-bis[(1-(ethylcarboxymethyl)-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-3-yl)methyl]-2-acetoxy-5-methylbenzene
• CAS No.: 286432-55-1
• Molecular Formula: C₂₇H₃₀N₄O₁₀
• Molecular Weight: 570.556
• Mol file: 286432-55-1.mol

Synonyms:1,3-bis[(1-(ethylcarboxymethyl)-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-3-yl)methyl]-2-acetoxy-5-methylbenzene

Chemical Property of 1,3-bis[(1-(ethylcarboxymethyl)-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-3-yl)methyl]-2-acetoxy-5-methylbenzene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,3-bis[(1-(ethylcarboxymethyl)-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-3-yl)methyl]-2-acetoxy-5-methylbenzene

There total 1 articles about 1,3-bis[(1-(ethylcarboxymethyl)-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-3-yl)methyl]-2-acetoxy-5-methylbenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

1,3-bis(bromomethyl)-2-acetoxy-5-methylbenzene (6453-01-6) + 1-(ethylcarboxymethyl)-1,2,3,4-tetrahydropyrimidine-2,4-dione (4113-98-8) → 1,3-bis[(1-(ethylcarboxymethyl)-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-3-yl)methyl]-2-acetoxy-5-methylbenzene (286432-55-1)

Guidance literature:

With tetra(n-butyl)ammonium hydrogensulfate; potassium carbonate; In acetonitrile; for 24h; Heating;

Reference yield: 85.0%

1,3-bis[(1-(ethylcarboxymethyl)-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-3-yl)methyl]-2-acetoxy-5-methylbenzene (286432-55-1) → 1,3-bis[(1-(carboxymethyl)-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-3-yl)methyl]-2-hydroxy-5-methylbenzene (286432-56-2)

Guidance literature:

With hydrogenchloride; In ethanol; water; for 36h; Heating;

Reference yield:

1,3-bis[(1-(ethylcarboxymethyl)-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-3-yl)methyl]-2-acetoxy-5-methylbenzene (286432-55-1) → 1,3-bis[(1-(ethylcarboxymethyl)-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-3-yl)methyl]-2-hydroxy-5-methylbenzene

Guidance literature:

Multi-step reaction with 2 steps

1: 85 percent / HCl / ethanol; H₂O / 36 h / Heating

2: 60 percent / p-TsOH / benzene / Heating

With hydrogenchloride; toluene-4-sulfonic acid; In ethanol; water; benzene; 1: Hydrolysis / 2: Esterification;

upstream raw materials:

1,3-bis(bromomethyl)-2-acetoxy-5-methylbenzene

1-(ethylcarboxymethyl)-1,2,3,4-tetrahydropyrimidine-2,4-dione

Downstream raw materials:

1,3-bis[(1-(carboxymethyl)-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-3-yl)methyl]-2-hydroxy-5-methylbenzene