(R)-sodium 3-[3-(3,4-dichlorophenylsulfanyl)-4-isopropyl-1H-pyrrolo[3,2-c]pyridin-2-yl]hexanoate

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Chemical Name:(R)-sodium 3-[3-(3,4-dichlorophenylsulfanyl)-4-isopropyl-1H-pyrrolo[3,2-c]pyridin-2-yl]hexanoate
CAS No.:1227479-76-6
Molecular Formula:C₂₁H₁₉Cl₂N₂O₂S*Na
Molecular Weight:457.356
Hs Code.:

Synonyms:(R)-sodium 3-[3-(3,4-dichlorophenylsulfanyl)-4-isopropyl-1H-pyrrolo[3,2-c]pyridin-2-yl]hexanoate

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Chemical Property of (R)-sodium 3-[3-(3,4-dichlorophenylsulfanyl)-4-isopropyl-1H-pyrrolo[3,2-c]pyridin-2-yl]hexanoate

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Technology Process of (R)-sodium 3-[3-(3,4-dichlorophenylsulfanyl)-4-isopropyl-1H-pyrrolo[3,2-c]pyridin-2-yl]hexanoate

There total 10 articles about (R)-sodium 3-[3-(3,4-dichlorophenylsulfanyl)-4-isopropyl-1H-pyrrolo[3,2-c]pyridin-2-yl]hexanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 887146-43-2
(R)-methyl 3-[3-(3,4-dichlorophenylsulfanyl)-4-isopropyl-1H-pyrrolo[3,2-c]pyridin-2-yl]hexanoate

: 1227479-76-6
(R)-sodium 3-[3-(3,4-dichlorophenylsulfanyl)-4-isopropyl-1H-pyrrolo[3,2-c]pyridin-2-yl]hexanoate

Guidance literature:: With sodium hydroxide; In methanol; water; at 50 ℃; for 2h;
DOI:10.1021/op100008m

Reference yield:

: 4-isopropyl-1H-pyrrolo[3,2-c]pyridine-2-carboxylic acid methyl ester trifluoroacetate

: 1227479-76-6
(R)-sodium 3-[3-(3,4-dichlorophenylsulfanyl)-4-isopropyl-1H-pyrrolo[3,2-c]pyridin-2-yl]hexanoate

Guidance literature:: Multi-step reaction with 9 steps

1.1: Isopropyl acetate; water / 20 - 30 °C / Large scale reaction

2.1: triethylamine / ethyl acetate / 0.5 h / 20 °C / Large scale reaction

3.1: lithium hydride / N,N-dimethyl-formamide / 10 - 65 °C / Large scale reaction

3.2: 5 - 30 °C / Large scale reaction

4.1: hydrogenchloride / methanol; water; toluene / 3 h / 95 °C / Large scale reaction

4.2: 1 h / 50 °C / Large scale reaction

5.1: sodium pentanolate / tetrahydrofuran / 2 h / 17 - 32 °C / Inert atmosphere; Large scale reaction

5.2: 23 h / -3 - 2 °C / Inert atmosphere; Large scale reaction

6.1: triethylamine / methanol / 0.5 h / 20 °C / Large scale reaction

7.1: Ir(COD)2BF₄; Walphos SLW₀₀₅-2; hydrogen / toluene / 24 h / 15 - 22 °C / 5414.51 Torr / Autoclave; Large scale reaction

8.1: N-chloro-succinimide / dichloromethane

9.1: sodium hydroxide / methanol; water / 2 h / 50 °C

With hydrogenchloride; N-chloro-succinimide; Ir(COD)2BF₄; Walphos SLW₀₀₅-2; hydrogen; lithium hydride; sodium pentanolate; triethylamine; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; Isopropyl acetate; water; ethyl acetate; N,N-dimethyl-formamide; toluene;
DOI:10.1021/op100008m

Reference yield:

: 1227479-80-2
4-isopropyl-1H-pyrrolo[3,2-c]pyridine-2-carboxylic acid methyl ester p-toluenesulfonate

: 1227479-76-6
(R)-sodium 3-[3-(3,4-dichlorophenylsulfanyl)-4-isopropyl-1H-pyrrolo[3,2-c]pyridin-2-yl]hexanoate

Guidance literature:: Multi-step reaction with 8 steps

1.1: triethylamine / ethyl acetate / 0.5 h / 20 °C / Large scale reaction

2.1: lithium hydride / N,N-dimethyl-formamide / 10 - 65 °C / Large scale reaction

2.2: 5 - 30 °C / Large scale reaction

3.1: hydrogenchloride / methanol; water; toluene / 3 h / 95 °C / Large scale reaction

3.2: 1 h / 50 °C / Large scale reaction

4.1: sodium pentanolate / tetrahydrofuran / 2 h / 17 - 32 °C / Inert atmosphere; Large scale reaction

4.2: 23 h / -3 - 2 °C / Inert atmosphere; Large scale reaction

5.1: triethylamine / methanol / 0.5 h / 20 °C / Large scale reaction

6.1: Ir(COD)2BF₄; Walphos SLW₀₀₅-2; hydrogen / toluene / 24 h / 15 - 22 °C / 5414.51 Torr / Autoclave; Large scale reaction

7.1: N-chloro-succinimide / dichloromethane

8.1: sodium hydroxide / methanol; water / 2 h / 50 °C

With hydrogenchloride; N-chloro-succinimide; Ir(COD)2BF₄; Walphos SLW₀₀₅-2; hydrogen; lithium hydride; sodium pentanolate; triethylamine; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; toluene;
DOI:10.1021/op100008m