2-Pyrrolidinone, 3,4-dihydroxy-5-(hydroxymethyl)-, [3S-(3alpha,4beta,5beta)]- (9CI)

Base Information

Chemical Name:2-Pyrrolidinone, 3,4-dihydroxy-5-(hydroxymethyl)-, [3S-(3alpha,4beta,5beta)]- (9CI)
CAS No.:186025-83-2
Molecular Formula:C₅H₉NO₄
Molecular Weight:147.131
Hs Code.:
Mol file:186025-83-2.mol

Synonyms:2-Pyrrolidinone,3,4-dihydroxy-5-(hydroxymethyl)-, [3S-(3a,4b,5b)]- (9CI)

Suppliers and Price of 2-Pyrrolidinone, 3,4-dihydroxy-5-(hydroxymethyl)-, [3S-(3alpha,4beta,5beta)]- (9CI)

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-Pyrrolidinone, 3,4-dihydroxy-5-(hydroxymethyl)-, [3S-(3alpha,4beta,5beta)]- (9CI)

Chemical Property:

PSA：89.79000
LogP:-2.47230

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 2-Pyrrolidinone, 3,4-dihydroxy-5-(hydroxymethyl)-, [3S-(3alpha,4beta,5beta)]- (9CI)

There total 1 articles about 2-Pyrrolidinone, 3,4-dihydroxy-5-(hydroxymethyl)-, [3S-(3alpha,4beta,5beta)]- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 157831-28-2
(3S,4R,5S)-3,4-dibenzyloxy-5-hydroxymethyl-pyrrolidin-2-one

: 186025-83-2,155102-96-8,783279-99-2
(3S,4R,5S)-3,4-Dihydroxy-5-hydroxymethyl-pyrrolidin-2-one

Guidance literature:: With hydrogen; palladium dihydroxide; In methanol; at 20 ℃; for 12h;
DOI:10.1016/S0040-4020(03)00379-X

Reference yield:

: 58479-61-1
tert-butylchlorodiphenylsilane

: 186025-83-2,155102-96-8,783279-99-2
(3S,4R,5S)-3,4-Dihydroxy-5-hydroxymethyl-pyrrolidin-2-one

: 562811-46-5
(3S,4R,5S)-5-(tert-butyldiphenylsiloxy)methyl-3,4-dihydroxypyrrolidin-2-one

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; at 20 ℃; for 12h;
DOI:10.1016/S0040-4020(03)00379-X

Reference yield:

: 186025-83-2,155102-96-8,783279-99-2
(3S,4R,5S)-3,4-Dihydroxy-5-hydroxymethyl-pyrrolidin-2-one

: 4-[(3R,4R,5S)-3-acetoxy-5-(tert-butyldiphenylsiloxy)methyl-4-(triethylsiloxy)pyrrolidin-2-ylidene]-2-[2-(E)-(benzyloxymethoxy)methyl-1-propenyl]-4H-oxazol-5-one

Guidance literature:: Multi-step reaction with 6 steps

1: 10.2 g / imidazole / dimethylformamide / 12 h / 20 °C

2: 89 percent / DMAP; pyridine / CH₂Cl₂ / 12 h / -23 - 20 °C

3: 90 percent / imidazole / dimethylformamide / 0.5 h / 20 °C

4: 97 percent / Lawesson's reagent / toluene / 0.67 h / 60 °C

5: 99 percent / CH₂Cl₂ / 3 h / 20 °C

6: pyridine; toluene / 12 h / 60 °C

With Lawessons reagent; pyridine; 1H-imidazole; dmap; In pyridine; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1016/S0040-4020(03)00379-X