3-benzenesulfonyl-3-(6-chloroimidazo[1,2-a]pyridin-2-yl)-1-phenylpropan-1-ol

Base Information

Chemical Name:3-benzenesulfonyl-3-(6-chloroimidazo[1,2-a]pyridin-2-yl)-1-phenylpropan-1-ol
CAS No.:478394-31-9
Molecular Formula:C₂₂H₁₉ClN₂O₃S
Molecular Weight:426.923
Hs Code.:

Synonyms:3-benzenesulfonyl-3-(6-chloroimidazo[1,2-a]pyridin-2-yl)-1-phenylpropan-1-ol

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Chemical Property of 3-benzenesulfonyl-3-(6-chloroimidazo[1,2-a]pyridin-2-yl)-1-phenylpropan-1-ol

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Technology Process of 3-benzenesulfonyl-3-(6-chloroimidazo[1,2-a]pyridin-2-yl)-1-phenylpropan-1-ol

There total 3 articles about 3-benzenesulfonyl-3-(6-chloroimidazo[1,2-a]pyridin-2-yl)-1-phenylpropan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 96-09-3
styrene oxide

: 478394-28-4
2-benzenesulfonylmethyl-6-chloroimidazo[1,2-a]pyridine

: 478394-31-9
3-benzenesulfonyl-3-(6-chloroimidazo[1,2-a]pyridin-2-yl)-1-phenylpropan-1-ol

Guidance literature:: 2-benzenesulfonylmethyl-6-chloroimidazo[1,2-a]pyridine; With Lithium dimsyl; In tetrahydrofuran; hexane; at 20 ℃; for 1h;

styrene oxide; In tetrahydrofuran; hexane; at 20 ℃; for 12h; Further stages.;
DOI:10.1021/ol026797b

Reference yield:

: 873-55-2
sodium benzenesulfonate

: 478394-31-9
3-benzenesulfonyl-3-(6-chloroimidazo[1,2-a]pyridin-2-yl)-1-phenylpropan-1-ol

Guidance literature:: Multi-step reaction with 3 steps

1.1: 64 percent / NBu₄HSO₄ / acetonitrile / 12 h / 20 °C

2.1: 66 percent / 1,2-dimethoxy-ethane / 48 h / Heating

3.1: LiCH₂SOCH₃ / tetrahydrofuran; hexane / 1 h / 20 °C

3.2: 89 percent / tetrahydrofuran; hexane / 12 h / 20 °C

With tetra(n-butyl)ammonium hydrogensulfate; Lithium dimsyl; In tetrahydrofuran; 1,2-dimethoxyethane; hexane; acetonitrile;
DOI:10.1021/ol026797b

Reference yield:

: 23886-96-6
1-chloro-3-phenylsulphonylpropane-2-one

: 478394-31-9
3-benzenesulfonyl-3-(6-chloroimidazo[1,2-a]pyridin-2-yl)-1-phenylpropan-1-ol

Guidance literature:: Multi-step reaction with 2 steps

1.1: 66 percent / 1,2-dimethoxy-ethane / 48 h / Heating

2.1: LiCH₂SOCH₃ / tetrahydrofuran; hexane / 1 h / 20 °C

2.2: 89 percent / tetrahydrofuran; hexane / 12 h / 20 °C

With Lithium dimsyl; In tetrahydrofuran; 1,2-dimethoxyethane; hexane;
DOI:10.1021/ol026797b