N-(5-(3,4-dimethylphenyl)-6-(2,2,2-trifluoroethoxy)pyridin-3-yl)-nicotinamide

Base Information

Chemical Name:N-(5-(3,4-dimethylphenyl)-6-(2,2,2-trifluoroethoxy)pyridin-3-yl)-nicotinamide
CAS No.:1372605-58-7
Molecular Formula:C₂₁H₁₈F₃N₃O₂
Molecular Weight:401.388
Hs Code.:

Synonyms:N-(5-(3,4-dimethylphenyl)-6-(2,2,2-trifluoroethoxy)pyridin-3-yl)-nicotinamide

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Chemical Property of N-(5-(3,4-dimethylphenyl)-6-(2,2,2-trifluoroethoxy)pyridin-3-yl)-nicotinamide

Chemical Property:

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Technology Process of N-(5-(3,4-dimethylphenyl)-6-(2,2,2-trifluoroethoxy)pyridin-3-yl)-nicotinamide

There total 4 articles about N-(5-(3,4-dimethylphenyl)-6-(2,2,2-trifluoroethoxy)pyridin-3-yl)-nicotinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 1372606-92-2
N-[5-Bromo-6-(2,2,2-trifluoro-ethoxy)-pyridin-3-yl]-nicotinamide

: 55499-43-9
3,4-dimethyl phenylboronic acid

: 1372605-58-7
N-(5-(3,4-dimethylphenyl)-6-(2,2,2-trifluoroethoxy)pyridin-3-yl)-nicotinamide

Guidance literature:: With sodium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In water; toluene; at 90 ℃; for 2h; Inert atmosphere;

Reference yield:

: 5470-17-7
3-bromo-2-chloro-5-nitropyridine

: 1372605-58-7
N-(5-(3,4-dimethylphenyl)-6-(2,2,2-trifluoroethoxy)pyridin-3-yl)-nicotinamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / mineral oil / 0.5 h / 0 - 25 °C / Inert atmosphere

1.2: 16 h / Reflux

2.1: hydrogenchloride; tin(ll) chloride / ethanol / 4 h / 25 °C

3.1: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl )-N,N,N' ,N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 3 h / Inert atmosphere

4.1: sodium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / toluene; water / 2 h / 90 °C / Inert atmosphere

With hydrogenchloride; O-(benzotriazol-1-yl )-N,N,N' ,N'-tetramethyluronium tetrafluoroborate; sodium hydride; sodium carbonate; N-ethyl-N,N-diisopropylamine; tin(ll) chloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In ethanol; water; N,N-dimethyl-formamide; toluene; mineral oil;

Reference yield:

: 1051372-09-8
3-bromo-5-nitro-2-(2,2,2-trifluoro-ethoxy)-pyridine

: 1372605-58-7
N-(5-(3,4-dimethylphenyl)-6-(2,2,2-trifluoroethoxy)pyridin-3-yl)-nicotinamide

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogenchloride; tin(ll) chloride / ethanol / 4 h / 25 °C

2: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl )-N,N,N' ,N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 3 h / Inert atmosphere

3: sodium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / toluene; water / 2 h / 90 °C / Inert atmosphere

With hydrogenchloride; O-(benzotriazol-1-yl )-N,N,N' ,N'-tetramethyluronium tetrafluoroborate; sodium carbonate; N-ethyl-N,N-diisopropylamine; tin(ll) chloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In ethanol; water; N,N-dimethyl-formamide; toluene;