C₁₅H₁₄F₅NO₂

Base Information

• Chemical Name: C₁₅H₁₄F₅NO₂
• CAS No.: 1292820-63-3
• Molecular Formula: C₁₅H₁₄F₅NO₂
• Molecular Weight: 335.274
• Mol file: 1292820-63-3.mol

Synonyms:C₁₅H₁₄F₅NO₂

Chemical Property of C₁₅H₁₄F₅NO₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₅H₁₄F₅NO₂

There total 2 articles about C₁₅H₁₄F₅NO₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

(furan-2-yloxy)-trimethylsilane (61550-02-5) + C11H10F5N (1292820-54-2) → C15H14F5NO2 (1292820-63-3)

Guidance literature:

(furan-2-yloxy)-trimethylsilane; C₁₁H₁₀F₅N; With ethanol; silver(I) acetate; (aS)-tBu-BinaphPHOX; In tetrahydrofuran; at -78 ℃; for 7h; Molecular sieve;

With acetic acid; In tetrahydrofuran; methanol; at -78 ℃; for 2h; enantioselective reaction;

DOI:10.1002/adsc.201000843

Reference yield:

(S)-1-phenyl-ethylamine (2627-86-3) → C15H14F5NO2 (1292820-63-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: toluene / Reflux

2.1: ethanol; silver(I) acetate; (aS)-tBu-BinaphPHOX / tetrahydrofuran / 7 h / -78 °C / Molecular sieve

2.2: 2 h / -78 °C

With ethanol; silver(I) acetate; (aS)-tBu-BinaphPHOX; In tetrahydrofuran; toluene; 2.1: Mannich type reaction;

DOI:10.1002/adsc.201000843

Reference yield:

C15H14F5NO2 (1292820-63-3) → C14H11BrF5NO3 (1292820-73-5)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogen; palladium(II) hydroxide / methanol / 7 h / 22 °C

2: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 12 h / 22 °C

With hydrogen; palladium(II) hydroxide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In methanol; N,N-dimethyl-formamide;

DOI:10.1002/adsc.201000843

upstream raw materials:

(furan-2-yloxy)-trimethylsilane

C₁₁H₁₀F₅N

(S)-1-phenyl-ethylamine

Downstream raw materials:

C₁₄H₁₁BrF₅NO₃

Refernces