1-(methoxycarbonyl)-α-hydroxy-3-cyclohexene-1-propanenitrile

Base Information

• Chemical Name: 1-(methoxycarbonyl)-α-hydroxy-3-cyclohexene-1-propanenitrile
• CAS No.: 99416-47-4
• Molecular Formula: C₁₁H₁₅NO₃
• Molecular Weight: 209.245
• Mol file: 99416-47-4.mol

Synonyms:1-(methoxycarbonyl)-α-hydroxy-3-cyclohexene-1-propanenitrile

Chemical Property of 1-(methoxycarbonyl)-α-hydroxy-3-cyclohexene-1-propanenitrile

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of 1-(methoxycarbonyl)-α-hydroxy-3-cyclohexene-1-propanenitrile

There total 5 articles about 1-(methoxycarbonyl)-α-hydroxy-3-cyclohexene-1-propanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

1-(methoxycarbonyl)-α-<(trimethylsilyl)oxy>-3-cyclohexene-1-propanenitrile (114595-91-4) → 1-(methoxycarbonyl)-α-hydroxy-3-cyclohexene-1-propanenitrile (99416-47-4)

Guidance literature:

With hydrogenchloride; In tetrahydrofuran; water;

DOI:10.1021/ja00311a111

Reference yield:

1-(methoxycarbonyl)-3-cyclohexene-1-acetaldehyde (114584-33-7) → 1-(methoxycarbonyl)-α-hydroxy-3-cyclohexene-1-propanenitrile (99416-47-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 71 percent / ZnI₂

2: 82 percent / HCl / H₂O; tetrahydrofuran

With hydrogenchloride; zinc(II) iodide; In tetrahydrofuran; water;

DOI:10.1021/ja00311a111

Reference yield:

1-(methoxycarbonyl)-3-cyclohexene-1-acetyl chloride (114584-32-6) → 1-(methoxycarbonyl)-α-hydroxy-3-cyclohexene-1-propanenitrile (99416-47-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 78 percent / (Ph₃P)2CuBH₄ / acetone

2: 71 percent / ZnI₂

3: 82 percent / HCl / H₂O; tetrahydrofuran

With hydrogenchloride; bis(triphenylphosphine)copper(I) tetrahydroborate; zinc(II) iodide; In tetrahydrofuran; water; acetone;

DOI:10.1021/ja00311a111

upstream raw materials:

1-(methoxycarbonyl)-α-<(trimethylsilyl)oxy>-3-cyclohexene-1-propanenitrile

1-(methoxycarbonyl)-3-cyclohexene-1-acetaldehyde

1-(methoxycarbonyl)-3-cyclohexene-1-acetyl chloride

1-(methoxycarbonyl)-3-cyclohexene-1-acetic acid