Technology Process of octyl 6-O-<2-O-(2-acetamido-3,4,6-tri-O-acetyl-2-deoxy-β-D-gluco-pyranosyl)-3,4,6-tri-O-benzyl-α-D-manno-pyranosyl>-4,8-anhydro-2,3-di-O-benzyl-7-deoxy-L-glycero-β-D-gluco-octopyranoside
There total 12 articles about octyl 6-O-<2-O-(2-acetamido-3,4,6-tri-O-acetyl-2-deoxy-β-D-gluco-pyranosyl)-3,4,6-tri-O-benzyl-α-D-manno-pyranosyl>-4,8-anhydro-2,3-di-O-benzyl-7-deoxy-L-glycero-β-D-gluco-octopyranoside which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 86 percent / tetramethylurea, silver trifluoromethanesulfonate / CH2Cl2 / 0.5 h / Ambient temperature
2: sodium methoxide / methanol / 1 h / Ambient temperature
3: silver trifluoromethanesulfonate, 2,6-lutidine, molecular sieves (4A) / CH2Cl2 / 1.) -50 deg C, 30 min, 2.) RT, 1 h
4: hydrazine hydrate / methanol / 10 h / Heating
5: pyridine / 5 h / Ambient temperature
With
pyridine; 2,6-dimethylpyridine; 4 A molecular sieve; sodium methylate; silver trifluoromethanesulfonate; hydrazine hydrate; tetramethylurea;
In
methanol; dichloromethane;
- Guidance literature:
-
Multi-step reaction with 9 steps
1: 78 percent / silver zeolite / CH2Cl2 / 2 h / Ambient temperature
2: 97 percent / sodium methoxide / methanol / Ambient temperature
3: 74 percent / 4-(N,N-dimethylamino)pyridine / CH2Cl2 / 1.) from 0 deg C to -18 deg C, 15 h, 2.) RT, 60 min
4: 63 percent / sodium hydride / dimethylformamide / 3 h / -50 - 20 °C
5: 86 percent / tetramethylurea, silver trifluoromethanesulfonate / CH2Cl2 / 0.5 h / Ambient temperature
6: sodium methoxide / methanol / 1 h / Ambient temperature
7: silver trifluoromethanesulfonate, 2,6-lutidine, molecular sieves (4A) / CH2Cl2 / 1.) -50 deg C, 30 min, 2.) RT, 1 h
8: hydrazine hydrate / methanol / 10 h / Heating
9: pyridine / 5 h / Ambient temperature
With
pyridine; 2,6-dimethylpyridine; dmap; 4 A molecular sieve; silver zeolite; sodium methylate; silver trifluoromethanesulfonate; sodium hydride; hydrazine hydrate; tetramethylurea;
In
methanol; dichloromethane; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 74 percent / 4-(N,N-dimethylamino)pyridine / CH2Cl2 / 1.) from 0 deg C to -18 deg C, 15 h, 2.) RT, 60 min
2: 63 percent / sodium hydride / dimethylformamide / 3 h / -50 - 20 °C
3: 86 percent / tetramethylurea, silver trifluoromethanesulfonate / CH2Cl2 / 0.5 h / Ambient temperature
4: sodium methoxide / methanol / 1 h / Ambient temperature
5: silver trifluoromethanesulfonate, 2,6-lutidine, molecular sieves (4A) / CH2Cl2 / 1.) -50 deg C, 30 min, 2.) RT, 1 h
6: hydrazine hydrate / methanol / 10 h / Heating
7: pyridine / 5 h / Ambient temperature
With
pyridine; 2,6-dimethylpyridine; dmap; 4 A molecular sieve; sodium methylate; silver trifluoromethanesulfonate; sodium hydride; hydrazine hydrate; tetramethylurea;
In
methanol; dichloromethane; N,N-dimethyl-formamide;
