(3-fluoro-4-morpholin-4-yl-phenyl)-(3-oxo-propyl)-carbamic acid benzyl ester

Base Information

• Chemical Name: (3-fluoro-4-morpholin-4-yl-phenyl)-(3-oxo-propyl)-carbamic acid benzyl ester
• CAS No.: 912552-55-7
• Molecular Formula: C₂₁H₂₃FN₂O₄
• Molecular Weight: 386.423
• Mol file: 912552-55-7.mol

Synonyms:(3-fluoro-4-morpholin-4-yl-phenyl)-(3-oxo-propyl)-carbamic acid benzyl ester

Chemical Property of (3-fluoro-4-morpholin-4-yl-phenyl)-(3-oxo-propyl)-carbamic acid benzyl ester

Chemical Property:

Purity/Quality:

98% HPLC ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (3-fluoro-4-morpholin-4-yl-phenyl)-(3-oxo-propyl)-carbamic acid benzyl ester

There total 3 articles about (3-fluoro-4-morpholin-4-yl-phenyl)-(3-oxo-propyl)-carbamic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

(3-fluoro-4-morpholin-4-yl-phenyl)-(3-hydroxy-propyl)-carbamic acid benzyl ester (912552-54-6) → (3-fluoro-4-morpholin-4-yl-phenyl)-(3-oxo-propyl)-carbamic acid benzyl ester (912552-55-7)

Guidance literature:

With oxalyl dichloride; dimethyl sulfoxide; triethylamine; In dichloromethane; at -78 - -60 ℃;

DOI:10.1016/j.tetlet.2006.07.065

Reference yield:

3-(3-fluoro-4-morpholin-4-yl-phenylamino)-propan-1-ol → (3-fluoro-4-morpholin-4-yl-phenyl)-(3-oxo-propyl)-carbamic acid benzyl ester (912552-55-7)

Guidance literature:

Multi-step reaction with 2 steps

1: aq. NaHCO₃ / acetone

2: 95 percent / (COCl)2; DMSO; Et₃N / CH₂Cl₂ / -78 - -60 °C

With oxalyl dichloride; sodium hydrogencarbonate; dimethyl sulfoxide; triethylamine; In dichloromethane; acetone; 2: Swern oxidation;

DOI:10.1016/j.tetlet.2006.07.065

Reference yield:

3-fluoro-4-(morpholinyl)aniline (93246-53-8) → (3-fluoro-4-morpholin-4-yl-phenyl)-(3-oxo-propyl)-carbamic acid benzyl ester (912552-55-7)

Guidance literature:

Multi-step reaction with 3 steps

1: NaI; Na₂CO₃ / dimethylformamide / 65 °C

2: aq. NaHCO₃ / acetone

3: 95 percent / (COCl)2; DMSO; Et₃N / CH₂Cl₂ / -78 - -60 °C

With oxalyl dichloride; sodium hydrogencarbonate; sodium carbonate; dimethyl sulfoxide; triethylamine; sodium iodide; In dichloromethane; N,N-dimethyl-formamide; acetone; 3: Swern oxidation;

DOI:10.1016/j.tetlet.2006.07.065

upstream raw materials:

(3-fluoro-4-morpholin-4-yl-phenyl)-(3-hydroxy-propyl)-carbamic acid benzyl ester

3-fluoro-4-(morpholinyl)aniline

Downstream raw materials:

(R)-methyl methanesulfonate

(R)-5-azidomethyl-3-(3-fluoro-4-(morpholin-4-yl)phenyl)oxazolidin-2-one

linezolid

(S)-N-[[3-[3-fluoro-4-[4-morpholinyl]phenyl]-2-oxo-5-oxazolidinyl]methyl]amine