3-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenoxy)-6,7-dihydro-8-phenyl-9-(4-ethoxyphenyl)-5H-benzocycloheptene

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Chemical Name:3-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenoxy)-6,7-dihydro-8-phenyl-9-(4-ethoxyphenyl)-5H-benzocycloheptene
CAS No.:1610422-63-3
Molecular Formula:C₃₂H₂₃F₇O₂
Molecular Weight:572.522
Hs Code.:

Synonyms:3-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenoxy)-6,7-dihydro-8-phenyl-9-(4-ethoxyphenyl)-5H-benzocycloheptene

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Chemical Property of 3-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenoxy)-6,7-dihydro-8-phenyl-9-(4-ethoxyphenyl)-5H-benzocycloheptene

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Technology Process of 3-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenoxy)-6,7-dihydro-8-phenyl-9-(4-ethoxyphenyl)-5H-benzocycloheptene

There total 5 articles about 3-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenoxy)-6,7-dihydro-8-phenyl-9-(4-ethoxyphenyl)-5H-benzocycloheptene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 1610422-60-0
3-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenoxy)-6,7-dihydro-8-bromo-9-(4-ethoxyphenyl)-5H-benzocycloheptene

: 591-51-5
phenyllithium

: 1610422-63-3
3-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenoxy)-6,7-dihydro-8-phenyl-9-(4-ethoxyphenyl)-5H-benzocycloheptene

Guidance literature:: phenyllithium; With zinc(II) chloride; In tetrahydrofuran; dibutyl ether; at 20 ℃; for 0.25h; Inert atmosphere;

3-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenoxy)-6,7-dihydro-8-bromo-9-(4-ethoxyphenyl)-5H-benzocycloheptene; With tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; dibutyl ether; at 20 ℃; for 6h; Inert atmosphere; Reflux;
DOI:10.1021/jm500569h

Reference yield:

: 6500-65-8
2-methoxy-6,7,8,9-tetrahydro-benzocyclohepten-5-one

: 1610422-63-3
3-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenoxy)-6,7-dihydro-8-phenyl-9-(4-ethoxyphenyl)-5H-benzocycloheptene

Guidance literature:: Multi-step reaction with 5 steps

1.1: aluminum (III) chloride / toluene / Reflux

2.1: sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate / dichloromethane; water / 20 °C / Inert atmosphere

3.1: ethylene dibromide; magnesium / diethyl ether / 1 h / Inert atmosphere

3.2: 20 °C / Inert atmosphere

3.3: 2 h / Inert atmosphere; Reflux

4.1: pyridinium hydrobromide perbromide / dichloromethane / 4 h / 20 °C / Inert atmosphere

5.1: zinc(II) chloride / tetrahydrofuran; dibutyl ether / 0.25 h / 20 °C / Inert atmosphere

5.2: 6 h / 20 °C / Inert atmosphere; Reflux

With aluminum (III) chloride; tetra(n-butyl)ammonium hydrogensulfate; magnesium; pyridinium hydrobromide perbromide; ethylene dibromide; sodium hydroxide; zinc(II) chloride; In tetrahydrofuran; diethyl ether; dichloromethane; dibutyl ether; water; toluene;
DOI:10.1021/jm500569h

Reference yield:

: 1610422-55-3
2-(4-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenoxy))-6,7,8,9-tetrahydro-5H-benzocyclohepten-5-one

: 1610422-63-3
3-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenoxy)-6,7-dihydro-8-phenyl-9-(4-ethoxyphenyl)-5H-benzocycloheptene

Guidance literature:: Multi-step reaction with 3 steps

1.1: ethylene dibromide; magnesium / diethyl ether / 1 h / Inert atmosphere

1.2: 20 °C / Inert atmosphere

1.3: 2 h / Inert atmosphere; Reflux

2.1: pyridinium hydrobromide perbromide / dichloromethane / 4 h / 20 °C / Inert atmosphere

3.1: zinc(II) chloride / tetrahydrofuran; dibutyl ether / 0.25 h / 20 °C / Inert atmosphere

3.2: 6 h / 20 °C / Inert atmosphere; Reflux

With magnesium; pyridinium hydrobromide perbromide; ethylene dibromide; zinc(II) chloride; In tetrahydrofuran; diethyl ether; dichloromethane; dibutyl ether;
DOI:10.1021/jm500569h