(2S,10S)-(+)-2,10-bis[p-(trifluoromethyl)phenyl]-1,11-bis(triphenylmethoxy)-3,6,9-trioxaundecane

Base Information

Chemical Name:(2S,10S)-(+)-2,10-bis[p-(trifluoromethyl)phenyl]-1,11-bis(triphenylmethoxy)-3,6,9-trioxaundecane
CAS No.:306281-97-0
Molecular Formula:C₆₀H₅₂F₆O₅
Molecular Weight:967.06
Hs Code.:

Synonyms:(2S,10S)-(+)-2,10-bis[p-(trifluoromethyl)phenyl]-1,11-bis(triphenylmethoxy)-3,6,9-trioxaundecane

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Chemical Property of (2S,10S)-(+)-2,10-bis[p-(trifluoromethyl)phenyl]-1,11-bis(triphenylmethoxy)-3,6,9-trioxaundecane

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Technology Process of (2S,10S)-(+)-2,10-bis[p-(trifluoromethyl)phenyl]-1,11-bis(triphenylmethoxy)-3,6,9-trioxaundecane

There total 3 articles about (2S,10S)-(+)-2,10-bis[p-(trifluoromethyl)phenyl]-1,11-bis(triphenylmethoxy)-3,6,9-trioxaundecane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

: 7460-82-4
diethylene glycol ditosylate

: 306281-94-7
(S)-(+)-1-[p-(trifluoromethyl)phenyl]-2-(triphenylmethoxy)ethanol

: 306281-97-0
(2S,10S)-(+)-2,10-bis[p-(trifluoromethyl)phenyl]-1,11-bis(triphenylmethoxy)-3,6,9-trioxaundecane

Guidance literature:: (S)-(+)-1-[p-(trifluoromethyl)phenyl]-2-(triphenylmethoxy)ethanol; With 15-crown-5; sodium hydride; In tetrahydrofuran; Heating;

diethylene glycol ditosylate; In tetrahydrofuran; Further stages.; Heating;

Reference yield:

: 402-50-6
1-trifluoromethyl-4-vinyl-benzene

: 306281-97-0
(2S,10S)-(+)-2,10-bis[p-(trifluoromethyl)phenyl]-1,11-bis(triphenylmethoxy)-3,6,9-trioxaundecane

Guidance literature:: Multi-step reaction with 3 steps

1.1: 90 percent / AD-mix-α; H2O / 2-methyl-propan-2-ol / 3 h / 0 °C

2.1: 79 percent / DMAP / dimethylformamide / 20 °C

3.1: NaH; 15-crown-5 / tetrahydrofuran / Heating

3.2: 38 percent / tetrahydrofuran / Heating

With dmap; AD-mix-α; 15-crown-5; water; sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide; tert-butyl alcohol; 1.1: Sharpless asymmetric dihydroxylation;

Reference yield:

: 306281-87-8
(+)-1-[p-(trifluoromethyl)phenyl]ethane-1,2-diol

: 306281-97-0
(2S,10S)-(+)-2,10-bis[p-(trifluoromethyl)phenyl]-1,11-bis(triphenylmethoxy)-3,6,9-trioxaundecane

Guidance literature:: Multi-step reaction with 2 steps

1.1: 79 percent / DMAP / dimethylformamide / 20 °C

2.1: NaH; 15-crown-5 / tetrahydrofuran / Heating

2.2: 38 percent / tetrahydrofuran / Heating

With dmap; 15-crown-5; sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide;