(2R,3R,4S)-5-((S)-4-Benzyl-2-oxo-oxazolidin-3-yl)-3-(tert-butyl-dimethyl-silanyloxy)-2,4-dimethyl-5-oxo-pentanal

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Chemical Name:(2R,3R,4S)-5-((S)-4-Benzyl-2-oxo-oxazolidin-3-yl)-3-(tert-butyl-dimethyl-silanyloxy)-2,4-dimethyl-5-oxo-pentanal
CAS No.:812649-72-2
Molecular Formula:C₂₃H₃₅NO₅Si
Molecular Weight:433.62
Hs Code.:

Synonyms:(2R,3R,4S)-5-((S)-4-Benzyl-2-oxo-oxazolidin-3-yl)-3-(tert-butyl-dimethyl-silanyloxy)-2,4-dimethyl-5-oxo-pentanal

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Chemical Property of (2R,3R,4S)-5-((S)-4-Benzyl-2-oxo-oxazolidin-3-yl)-3-(tert-butyl-dimethyl-silanyloxy)-2,4-dimethyl-5-oxo-pentanal

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Technology Process of (2R,3R,4S)-5-((S)-4-Benzyl-2-oxo-oxazolidin-3-yl)-3-(tert-butyl-dimethyl-silanyloxy)-2,4-dimethyl-5-oxo-pentanal

There total 2 articles about (2R,3R,4S)-5-((S)-4-Benzyl-2-oxo-oxazolidin-3-yl)-3-(tert-butyl-dimethyl-silanyloxy)-2,4-dimethyl-5-oxo-pentanal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 812649-71-1
(S)-4-benzyl-3-{(2S,3R,4S)-3-hydroxy-5-[(4-methoxybenzyl)oxy]-2,4-dimethylpentanoyl}oxazolidin-2-one

: 812649-72-2
(2R,3R,4S)-5-((S)-4-Benzyl-2-oxo-oxazolidin-3-yl)-3-(tert-butyl-dimethyl-silanyloxy)-2,4-dimethyl-5-oxo-pentanal

Guidance literature:: Multi-step reaction with 3 steps

1.1: 2,6-lutidine / CH₂Cl₂ / 78 °C

2.1: DDQ / CH₂Cl₂ / 3.5 h / 0 °C / pH 7

3.1: DMSO; C₂O₂Cl₂ / CH₂Cl₂ / 1.25 h / -78 °C

3.2: 100 percent / Et₃N / CH₂Cl₂ / 0.5 h / -78 - 0 °C

With 2,6-dimethylpyridine; oxalyl dichloride; dimethyl sulfoxide; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In dichloromethane; 3.1: Swern oxidation;
DOI:10.1016/j.tetlet.2004.09.150

Reference yield:

: (S)-4-Benzyl-3-[(2S,3R,4S)-3-(tert-butyl-dimethyl-silanyloxy)-5-(4-methoxy-benzyloxy)-2,4-dimethyl-pentanoyl]-oxazolidin-2-one

: 812649-72-2
(2R,3R,4S)-5-((S)-4-Benzyl-2-oxo-oxazolidin-3-yl)-3-(tert-butyl-dimethyl-silanyloxy)-2,4-dimethyl-5-oxo-pentanal

Guidance literature:: Multi-step reaction with 2 steps

1.1: DDQ / CH₂Cl₂ / 3.5 h / 0 °C / pH 7

2.1: DMSO; C₂O₂Cl₂ / CH₂Cl₂ / 1.25 h / -78 °C

2.2: 100 percent / Et₃N / CH₂Cl₂ / 0.5 h / -78 - 0 °C

With oxalyl dichloride; dimethyl sulfoxide; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In dichloromethane; 2.1: Swern oxidation;
DOI:10.1016/j.tetlet.2004.09.150