2-{2-[(S)-3-tert-butoxy-2-(9H-fluoren-9-ylmethoxycarbonylamino)propionylamino]phenylethynyl}benzoic acid

Base Information

Chemical Name:2-{2-[(S)-3-tert-butoxy-2-(9H-fluoren-9-ylmethoxycarbonylamino)propionylamino]phenylethynyl}benzoic acid
CAS No.:1364421-82-8
Molecular Formula:C₃₇H₃₄N₂O₆
Molecular Weight:602.687
Hs Code.:

Synonyms:2-{2-[(S)-3-tert-butoxy-2-(9H-fluoren-9-ylmethoxycarbonylamino)propionylamino]phenylethynyl}benzoic acid

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Chemical Property of 2-{2-[(S)-3-tert-butoxy-2-(9H-fluoren-9-ylmethoxycarbonylamino)propionylamino]phenylethynyl}benzoic acid

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Technology Process of 2-{2-[(S)-3-tert-butoxy-2-(9H-fluoren-9-ylmethoxycarbonylamino)propionylamino]phenylethynyl}benzoic acid

There total 7 articles about 2-{2-[(S)-3-tert-butoxy-2-(9H-fluoren-9-ylmethoxycarbonylamino)propionylamino]phenylethynyl}benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₇H₃₆N₂O₅

: 1364421-82-8
2-{2-[(S)-3-tert-butoxy-2-(9H-fluoren-9-ylmethoxycarbonylamino)propionylamino]phenylethynyl}benzoic acid

Guidance literature:: With Jones reagent; In acetone; at 20 ℃; for 2h;
DOI:10.1021/jo202604q

Reference yield:

: 610-97-9
o-iodo-methyl-benzoic acid

: 1364421-82-8
2-{2-[(S)-3-tert-butoxy-2-(9H-fluoren-9-ylmethoxycarbonylamino)propionylamino]phenylethynyl}benzoic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: trans-bis(triphenylphosphine)palladium dichloride; triethylamine; triphenylphosphine / tetrahydrofuran / 0.33 h / Inert atmosphere

1.2: 18 h / 20 °C / Inert atmosphere

2.1: piperidine; trans-bis(triphenylphosphine)palladium dichloride; triphenylphosphine / tetrahydrofuran / 0.33 h / Inert atmosphere

2.2: 18 h / Inert atmosphere; Reflux

3.1: silver cyanide / dichloromethane / 2 h / 20 °C / Inert atmosphere; Darkness

4.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.33 h / Inert atmosphere; Cooling with ice

5.1: Jones reagent / acetone / 2 h / 20 °C

With piperidine; lithium aluminium tetrahydride; Jones reagent; silver cyanide; trans-bis(triphenylphosphine)palladium dichloride; triethylamine; triphenylphosphine; In tetrahydrofuran; dichloromethane; acetone; 1.1: Sonogashira coupling / 1.2: Sonogashira coupling / 2.1: Sonogashira coupling / 2.2: Sonogashira coupling;
DOI:10.1021/jo202604q

Reference yield:

: 1364421-74-8
2-{2-[(S)-3-tert-butoxy-2-(9H-fluoren-9-ylmethoxycarbonylamino)propionylamino]phenylethynyl}benzoic acid methyl ester

: 1364421-82-8
2-{2-[(S)-3-tert-butoxy-2-(9H-fluoren-9-ylmethoxycarbonylamino)propionylamino]phenylethynyl}benzoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 0.33 h / Inert atmosphere; Cooling with ice

2: Jones reagent / acetone / 2 h / 20 °C

With lithium aluminium tetrahydride; Jones reagent; In tetrahydrofuran; acetone;
DOI:10.1021/jo202604q