[(S)-3-Cyano-1-cyclohexylmethyl-2-oxo-3-(triphenyl-λ⁵-phosphanylidene)-propyl]-carbamic acid 1-isopropyl-2-methyl-propyl ester

Base Information

• Chemical Name: [(S)-3-Cyano-1-cyclohexylmethyl-2-oxo-3-(triphenyl-λ⁵-phosphanylidene)-propyl]-carbamic acid 1-isopropyl-2-methyl-propyl ester
• CAS No.: 660853-72-5
• Molecular Formula: C₃₇H₄₅N₂O₃P
• Molecular Weight: 596.75

Synonyms:[(S)-3-Cyano-1-cyclohexylmethyl-2-oxo-3-(triphenyl-λ⁵-phosphanylidene)-propyl]-carbamic acid 1-isopropyl-2-methyl-propyl ester

Chemical Property of [(S)-3-Cyano-1-cyclohexylmethyl-2-oxo-3-(triphenyl-λ⁵-phosphanylidene)-propyl]-carbamic acid 1-isopropyl-2-methyl-propyl ester

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Technology Process of [(S)-3-Cyano-1-cyclohexylmethyl-2-oxo-3-(triphenyl-λ⁵-phosphanylidene)-propyl]-carbamic acid 1-isopropyl-2-methyl-propyl ester

There total 4 articles about [(S)-3-Cyano-1-cyclohexylmethyl-2-oxo-3-(triphenyl-λ⁵-phosphanylidene)-propyl]-carbamic acid 1-isopropyl-2-methyl-propyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

cyanomethylene triphenylphosphorane (16640-68-9) + (S)-3-Cyclohexyl-2-(1-isopropyl-2-methyl-propoxycarbonylamino)-propionic acid → [(S)-3-Cyano-1-cyclohexylmethyl-2-oxo-3-(triphenyl-λ5-phosphanylidene)-propyl]-carbamic acid 1-isopropyl-2-methyl-propyl ester (660853-72-5)

Guidance literature:

With dmap; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In dichloromethane; at 20 ℃;

DOI:10.1021/jm030373l

Reference yield:

2,4-dimethyl-3-pentanol (600-36-2) → [(S)-3-Cyano-1-cyclohexylmethyl-2-oxo-3-(triphenyl-λ5-phosphanylidene)-propyl]-carbamic acid 1-isopropyl-2-methyl-propyl ester (660853-72-5)

Guidance literature:

Multi-step reaction with 4 steps

1: tetrahydrofuran; toluene / 20 °C

2: Hunig's base / tetrahydrofuran / 20 °C

3: aq. LiOH / tetrahydrofuran / 20 °C

4: EDC; DMAP / CH₂Cl₂ / 20 °C

With dmap; lithium hydroxide; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; toluene;

DOI:10.1021/jm030373l

Reference yield:

2,4-dimethyl-3-pentyl chloroformate (30250-57-8) → [(S)-3-Cyano-1-cyclohexylmethyl-2-oxo-3-(triphenyl-λ5-phosphanylidene)-propyl]-carbamic acid 1-isopropyl-2-methyl-propyl ester (660853-72-5)

Guidance literature:

Multi-step reaction with 3 steps

1: Hunig's base / tetrahydrofuran / 20 °C

2: aq. LiOH / tetrahydrofuran / 20 °C

3: EDC; DMAP / CH₂Cl₂ / 20 °C

With dmap; lithium hydroxide; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane;

DOI:10.1021/jm030373l

upstream raw materials:

cyanomethylene triphenylphosphorane

2,4-dimethyl-3-pentanol

2,4-dimethyl-3-pentyl chloroformate

(S)-3-Cyclohexyl-2-(1-isopropyl-2-methyl-propoxycarbonylamino)-propionic acid methyl ester

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