N-(1-Cyclohexen-1-yl)-N-lithiobenzolamin

Base Information

• Chemical Name: N-(1-Cyclohexen-1-yl)-N-lithiobenzolamin
• CAS No.: 75251-09-1
• Molecular Formula: C₁₂H₁₄N*Li
• Molecular Weight: 179.191
• Mol file: 75251-09-1.mol

Synonyms:N-(1-Cyclohexen-1-yl)-N-lithiobenzolamin

Chemical Property of N-(1-Cyclohexen-1-yl)-N-lithiobenzolamin

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(1-Cyclohexen-1-yl)-N-lithiobenzolamin

There total 2 articles about N-(1-Cyclohexen-1-yl)-N-lithiobenzolamin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

N-cyclohexylidenebenzenamine (1132-38-3) → N-(1-Cyclohexen-1-yl)-N-lithiobenzolamin (75251-09-1)

Guidance literature:

With lithium diisopropyl amide; In diethyl ether; at -78 - 23 ℃; for 20h;

DOI:10.1021/acs.inorgchem.5b02990

Reference yield:

cyclohexanone (108-94-1,11119-77-0,9003-41-2,9075-99-4) → N-(1-Cyclohexen-1-yl)-N-lithiobenzolamin (75251-09-1)

Guidance literature:

Multi-step reaction with 2 steps

1: toluene-4-sulfonic acid / toluene / 48 h / 23 °C / Molecular sieve; Reflux

2: lithium diisopropyl amide / diethyl ether / 20 h / -78 - 23 °C

With toluene-4-sulfonic acid; lithium diisopropyl amide; In diethyl ether; toluene;

DOI:10.1021/acs.inorgchem.5b02990

Reference yield: 54.0%

N-(1-Cyclohexen-1-yl)-N-lithiobenzolamin (75251-09-1) → 9-phenyl-1,2,3,4,5,6,7,8-octahydro-carbazole (54212-07-6)

Guidance literature:

With chromium chloride; In tetrahydrofuran; at -78 ℃; for 24h; Reflux;

DOI:10.1021/acs.inorgchem.5b02990

upstream raw materials:

N-cyclohexylidenebenzenamine

cyclohexanone

Downstream raw materials:

N-(1-Cyclohexen-1-yl)benzolamin

N-cyclohexenyl-N-methylbenzenamine

9-phenyl-1,2,3,4,5,6,7,8-octahydro-carbazole

Refernces

• 1、 Knorr, Rudolf,Weiss, Alfons,Loew, Peter,Raepple, Edith. "Azomethines, 1-Azaallyl Anions, and Metastable Secondary Enamines". . p. 2462 - 2489. Retrieved 2007/10/02.