toluene-4-sulfonic acid 2-[2-(2-[¹⁸F]-fluoroethoxy)ethoxy]ethyl ester

Base Information

• Chemical Name: toluene-4-sulfonic acid 2-[2-(2-[¹⁸F]-fluoroethoxy)ethoxy]ethyl ester
• CAS No.: 1423135-40-3
• Molecular Formula: C₁₃H₁₉FO₅S
• Molecular Weight: 305.357
• Mol file: 1423135-40-3.mol

Synonyms:toluene-4-sulfonic acid 2-[2-(2-[¹⁸F]-fluoroethoxy)ethoxy]ethyl ester

Chemical Property of toluene-4-sulfonic acid 2-[2-(2-[¹⁸F]-fluoroethoxy)ethoxy]ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of toluene-4-sulfonic acid 2-[2-(2-[¹⁸F]-fluoroethoxy)ethoxy]ethyl ester

There total 1 articles about toluene-4-sulfonic acid 2-[2-(2-[¹⁸F]-fluoroethoxy)ethoxy]ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.0%

triethylene glycol di-(p-toluenesulfonate) (19249-03-7) → toluene-4-sulfonic acid 2-[2-(2-[18F]-fluoroethoxy)ethoxy]ethyl ester (1423135-40-3)

Guidance literature:

With potassium carbonate; [2.2.2]cryptande; In water; acetonitrile; at 110 ℃; for 0.166667h;

Reference yield: 3.7%

4-((2-aminophenyl)thio)-3-((dimethylamino)methyl)phenol (1004534-87-5) + toluene-4-sulfonic acid 2-[2-(2-[18F]-fluoroethoxy)ethoxy]ethyl ester (1423135-40-3) → C21H29(18)FN2O3S

Guidance literature:

In N,N-dimethyl-formamide; at 120 ℃; for 0.25h; Inert atmosphere;

Reference yield:

toluene-4-sulfonic acid 2-[2-(2-[18F]-fluoroethoxy)ethoxy]ethyl ester (1423135-40-3) + tert-butyl 4-{3-[(3R)-3-{[(1S)-1-(3-hydroxyphenyl)-3-methoxy-3-oxopropyl]carbamoyl}piperidin-1-yl]-3-oxopropyl}piperidine-1-carboxylate (1423134-77-3) → (3S)-3-(3-{2-[2-(2-[18F]fluoroethoxy)ethoxy]ethoxy}phenyl)-3-[({(3R)-1-[3-(piperidin-4-yl)propanoyl]piperidin-3-yl}carbonyl)amino]propanoic acid (1423134-59-1)

Guidance literature:

tert-butyl 4-{3-[(3R)-3-{[(1S)-1-(3-hydroxyphenyl)-3-methoxy-3-oxopropyl]carbamoyl}piperidin-1-yl]-3-oxopropyl}piperidine-1-carboxylate; With sodium hydroxide; In N,N-dimethyl-formamide; at 25 ℃; for 0.0166667h; Sealed tube;

toluene-4-sulfonic acid 2-[2-(2-[¹⁸F]-fluoroethoxy)ethoxy]ethyl ester; With hydrogenchloride; sodium hydroxide; In water; N,N-dimethyl-formamide; at 25 - 100 ℃; for 0.5h; Sealed tube;

upstream raw materials:

triethylene glycol di-(p-toluenesulfonate)

Downstream raw materials:

(3S)-3-(3-{2-[2-(2-[¹⁸F]fluoroethoxy)ethoxy]ethoxy}phenyl)-3-[({(3R)-1-[3-(piperidin-4-yl)propanoyl]piperidin-3-yl}carbonyl)amino]propanoic acid