Technology Process of ((R)-1,3,3-Trimethyl-2-methylene-cyclohexyl)-acetic acid
There total 11 articles about ((R)-1,3,3-Trimethyl-2-methylene-cyclohexyl)-acetic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sodium hydroxide;
In
methanol;
for 12h;
Heating;
DOI:10.1021/jo0105484
- Guidance literature:
-
Multi-step reaction with 10 steps
1: diethyl ether / 0 - 20 °C
2: 750 mg / PCC; silica gel / CH2Cl2 / 12 h
3: 90 percent / NBS / CH2Cl2; methanol / 6 h / 0 - 5 °C
4: 76 percent / potassium tert-butoxide / tetrahydrofuran / -5 - 20 °C
5: O3; NaHCO3 / CH2Cl2 / 0.08 h / -70 °C
6: 93 mg / Ac2O; Et3N; 4-N,N-(dimethylamino)pyridine / benzene / 6 h / Heating
7: 90 percent / H2 / Pd/C / ethyl acetate / 0.5 h
8: 60 percent Turnov. / BF3*OEt2 / benzene / 2 h / 0 - 5 °C
9: 90 percent / Raney Ni / ethanol / 0.5 h / Heating
10: 94 percent / aq. NaOH / methanol / 12 h / Heating
With
dmap; sodium hydroxide; N-Bromosuccinimide; boron trifluoride diethyl etherate; potassium tert-butylate; hydrogen; acetic anhydride; silica gel; nickel; sodium hydrogencarbonate; ozone; triethylamine; pyridinium chlorochromate;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; diethyl ether; ethanol; dichloromethane; ethyl acetate; benzene;
6: Criegee rearrangement;
DOI:10.1021/jo0105484
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 90 percent / H2 / Pd/C / ethyl acetate / 0.5 h
2: 60 percent Turnov. / BF3*OEt2 / benzene / 2 h / 0 - 5 °C
3: 90 percent / Raney Ni / ethanol / 0.5 h / Heating
4: 94 percent / aq. NaOH / methanol / 12 h / Heating
With
sodium hydroxide; boron trifluoride diethyl etherate; hydrogen; nickel;
palladium on activated charcoal;
In
methanol; ethanol; ethyl acetate; benzene;
DOI:10.1021/jo0105484
