Carbonic acid (1R,2S,5R)-2-isopropyl-5-methyl-1-((E)-propenyl)-cyclohexyl ester methyl ester

Base Information

• Chemical Name: Carbonic acid (1R,2S,5R)-2-isopropyl-5-methyl-1-((E)-propenyl)-cyclohexyl ester methyl ester
• CAS No.: 217321-04-5
• Molecular Formula: C₁₅H₂₆O₃
• Molecular Weight: 254.37
• Mol file: 217321-04-5.mol

Synonyms:Carbonic acid (1R,2S,5R)-2-isopropyl-5-methyl-1-((E)-propenyl)-cyclohexyl ester methyl ester

Chemical Property of Carbonic acid (1R,2S,5R)-2-isopropyl-5-methyl-1-((E)-propenyl)-cyclohexyl ester methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Carbonic acid (1R,2S,5R)-2-isopropyl-5-methyl-1-((E)-propenyl)-cyclohexyl ester methyl ester

There total 6 articles about Carbonic acid (1R,2S,5R)-2-isopropyl-5-methyl-1-((E)-propenyl)-cyclohexyl ester methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2R,5S)-menthone (10458-14-7,14073-97-3,17627-49-5,7786-64-3) → Carbonic acid (1R,2S,5R)-2-isopropyl-5-methyl-1-((E)-propenyl)-cyclohexyl ester methyl ester (217321-04-5)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrahydrofuran / -78 °C

2: n-BuLi / tetrahydrofuran

With n-butyllithium; In tetrahydrofuran;

DOI:10.1021/ja982525l

Reference yield:

(1S,2S,5R)-2-i-propyl-5-methyl-1-(1-propyn-1-yl)cyclohexan-1-ol (33651-09-1) → Carbonic acid (1R,2S,5R)-2-isopropyl-5-methyl-1-((E)-propenyl)-cyclohexyl ester methyl ester (217321-04-5)

Guidance literature:

Multi-step reaction with 2 steps

1: Red-Al / tetrahydrofuran

2: n-BuLi / tetrahydrofuran

With n-butyllithium; sodium bis(2-methoxyethoxy)aluminium dihydride; In tetrahydrofuran;

DOI:10.1021/ja982525l

Reference yield:

(1S,2S,5R)-2-isopropyl-5-methyl-1-{1-propen-1-yl}cyclohexan-1-ol (83803-22-9) + carbonic acid dimethyl ester (616-38-6) → Carbonic acid (1R,2S,5R)-2-isopropyl-5-methyl-1-((E)-propenyl)-cyclohexyl ester methyl ester (217321-04-5)

Guidance literature:

With n-butyllithium; In tetrahydrofuran;

DOI:10.1021/ja982525l

upstream raw materials:

(1S,2S,5R)-2-isopropyl-5-methyl-1-{1-propen-1-yl}cyclohexan-1-ol

carbonic acid dimethyl ester

methyl chloroformate

(2R,5S)-menthone

Downstream raw materials:

(1S,4R)-2-[(R)-2-Cyclohexyl-prop-(E)-ylidene]-1-isopropyl-4-methyl-cyclohexane

(1S,4R)-1-Isopropyl-4-methyl-2-[(R)-2-methyl-but-(E)-ylidene]-cyclohexane

(1S,4R)-1-Isopropyl-4-methyl-2-[(S)-2,3,3-trimethyl-but-(E)-ylidene]-cyclohexane

(1S,4R)-1-Isopropyl-4-methyl-2-[(R)-2-methyl-hex-(E)-ylidene]-cyclohexane