1-[(5-bromo-2,3-dihydro-2,2-dimethyl-benzofuran-7-yl)-oxy]-4-[4-(3-trifluoromethyl-phenyl)-1,2,5,6-tetrahydro-pyridin-1-yl]-butane hydrochloride

Base Information

Chemical Name:1-[(5-bromo-2,3-dihydro-2,2-dimethyl-benzofuran-7-yl)-oxy]-4-[4-(3-trifluoromethyl-phenyl)-1,2,5,6-tetrahydro-pyridin-1-yl]-butane hydrochloride
CAS No.:1089209-61-9
Molecular Formula:C₂₆H₂₉BrF₃NO₂*ClH
Molecular Weight:560.882
Hs Code.:

Synonyms:1-[(5-bromo-2,3-dihydro-2,2-dimethyl-benzofuran-7-yl)-oxy]-4-[4-(3-trifluoromethyl-phenyl)-1,2,5,6-tetrahydro-pyridin-1-yl]-butane hydrochloride

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Chemical Property of 1-[(5-bromo-2,3-dihydro-2,2-dimethyl-benzofuran-7-yl)-oxy]-4-[4-(3-trifluoromethyl-phenyl)-1,2,5,6-tetrahydro-pyridin-1-yl]-butane hydrochloride

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Technology Process of 1-[(5-bromo-2,3-dihydro-2,2-dimethyl-benzofuran-7-yl)-oxy]-4-[4-(3-trifluoromethyl-phenyl)-1,2,5,6-tetrahydro-pyridin-1-yl]-butane hydrochloride

There total 3 articles about 1-[(5-bromo-2,3-dihydro-2,2-dimethyl-benzofuran-7-yl)-oxy]-4-[4-(3-trifluoromethyl-phenyl)-1,2,5,6-tetrahydro-pyridin-1-yl]-butane hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1089758-65-5
1-[(5-bromo-2,3-dihydro-2,2-dimethyl-benzofuran-7-yl)-oxy]-4-[4-(3-trifluoromethyl-phenyl)-1,2,5,6-tetrahydro-pyridin-1-yl]-butane

: 1089209-61-9
1-[(5-bromo-2,3-dihydro-2,2-dimethyl-benzofuran-7-yl)-oxy]-4-[4-(3-trifluoromethyl-phenyl)-1,2,5,6-tetrahydro-pyridin-1-yl]-butane hydrochloride

Guidance literature:: With hydrogenchloride; In diethyl ether; isopropyl alcohol;

Reference yield:

: 250289-97-5
5-bromo-2,2-dimethyl-2,3-dihydrobenzofuran-7-ol

: 1089209-61-9
1-[(5-bromo-2,3-dihydro-2,2-dimethyl-benzofuran-7-yl)-oxy]-4-[4-(3-trifluoromethyl-phenyl)-1,2,5,6-tetrahydro-pyridin-1-yl]-butane hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride / dichloromethane; water / 4 h / 20 - 40 °C

2: sodium methylate / methanol / 6 h / 20 °C / Heating / reflux

3: hydrogenchloride / diethyl ether; isopropyl alcohol

With hydrogenchloride; sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride; sodium methylate; In methanol; diethyl ether; dichloromethane; water; isopropyl alcohol;

Reference yield:

: 1089210-23-0
5-bromo-2,3-dihydro-2,2-dimethyl-7-(4-bromo-butoxy)-benzofuran

: 1089209-61-9
1-[(5-bromo-2,3-dihydro-2,2-dimethyl-benzofuran-7-yl)-oxy]-4-[4-(3-trifluoromethyl-phenyl)-1,2,5,6-tetrahydro-pyridin-1-yl]-butane hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: sodium methylate / methanol / 6 h / 20 °C / Heating / reflux

2: hydrogenchloride / diethyl ether; isopropyl alcohol

With hydrogenchloride; sodium methylate; In methanol; diethyl ether; isopropyl alcohol;