[(1S)-2-(3,5-dichloro-1-oxido-pyridin-1-ium-4-yl)-1-(3,4-dimethoxyphenyl)-ethyl]-4-(1,3-dioxolan-2-ylmethyl)benzoate

Base Information

Chemical Name:[(1S)-2-(3,5-dichloro-1-oxido-pyridin-1-ium-4-yl)-1-(3,4-dimethoxyphenyl)-ethyl]-4-(1,3-dioxolan-2-ylmethyl)benzoate
CAS No.:1611455-46-9
Molecular Formula:C₂₆H₂₅Cl₂NO₇
Molecular Weight:534.393
Hs Code.:

Synonyms:[(1S)-2-(3,5-dichloro-1-oxido-pyridin-1-ium-4-yl)-1-(3,4-dimethoxyphenyl)-ethyl]-4-(1,3-dioxolan-2-ylmethyl)benzoate

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Chemical Property of [(1S)-2-(3,5-dichloro-1-oxido-pyridin-1-ium-4-yl)-1-(3,4-dimethoxyphenyl)-ethyl]-4-(1,3-dioxolan-2-ylmethyl)benzoate

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Technology Process of [(1S)-2-(3,5-dichloro-1-oxido-pyridin-1-ium-4-yl)-1-(3,4-dimethoxyphenyl)-ethyl]-4-(1,3-dioxolan-2-ylmethyl)benzoate

There total 7 articles about [(1S)-2-(3,5-dichloro-1-oxido-pyridin-1-ium-4-yl)-1-(3,4-dimethoxyphenyl)-ethyl]-4-(1,3-dioxolan-2-ylmethyl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 898767-03-8
4-((1,3-dioxolan-2-yl)methyl)benzoic acid

: 1415994-42-1
(1S)-2-(3,5-dichloro-1-oxido-pyridin-1-ium-4-yl)-1-(3,4-dimethoxyphenyl)-ethanol

: 1611455-46-9
[(1S)-2-(3,5-dichloro-1-oxido-pyridin-1-ium-4-yl)-1-(3,4-dimethoxyphenyl)-ethyl]-4-(1,3-dioxolan-2-ylmethyl)benzoate

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 18h;

Reference yield:

: 120-14-9
3,4-dimethoxy-benzaldehyde

: 1611455-46-9
[(1S)-2-(3,5-dichloro-1-oxido-pyridin-1-ium-4-yl)-1-(3,4-dimethoxyphenyl)-ethyl]-4-(1,3-dioxolan-2-ylmethyl)benzoate

Guidance literature:: Multi-step reaction with 6 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

1.2: -78 °C

2.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 2 h / 20 °C

3.1: methanol; chloroform / 2 h / 20 °C

4.1: potassium tert-butylate; methanol / toluene / 24 h / 20 °C

5.1: 3-chloro-benzenecarboperoxoic acid / ethyl acetate / 5 h / 20 °C

6.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 18 h / 20 °C

With methanol; dmap; potassium tert-butylate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 3-chloro-benzenecarboperoxoic acid; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; dichloromethane; chloroform; ethyl acetate; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1113061-23-6
(R,S)-2-(3,5-dichloropyridin-4-yl)-1-(3,4-dimethoxyphenyl)ethanol

: 1611455-46-9
[(1S)-2-(3,5-dichloro-1-oxido-pyridin-1-ium-4-yl)-1-(3,4-dimethoxyphenyl)-ethyl]-4-(1,3-dioxolan-2-ylmethyl)benzoate

Guidance literature:: Multi-step reaction with 5 steps

1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 2 h / 20 °C

2: methanol; chloroform / 2 h / 20 °C

3: potassium tert-butylate; methanol / toluene / 24 h / 20 °C

4: 3-chloro-benzenecarboperoxoic acid / ethyl acetate / 5 h / 20 °C

5: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 18 h / 20 °C

With methanol; dmap; potassium tert-butylate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 3-chloro-benzenecarboperoxoic acid; In methanol; dichloromethane; chloroform; ethyl acetate; N,N-dimethyl-formamide; toluene;