5-(2-fluoro-4-methanesulfonyl-phenyl)-2-[1-(1-trifluoromethyl-cyclopropylmethyl)-piperidin-4-yl]-furo[2,3-c]pyridine

Base Information

Chemical Name:5-(2-fluoro-4-methanesulfonyl-phenyl)-2-[1-(1-trifluoromethyl-cyclopropylmethyl)-piperidin-4-yl]-furo[2,3-c]pyridine
CAS No.:1451163-44-2
Molecular Formula:C₂₄H₂₄F₄N₂O₃S
Molecular Weight:496.526
Hs Code.:

Synonyms:5-(2-fluoro-4-methanesulfonyl-phenyl)-2-[1-(1-trifluoromethyl-cyclopropylmethyl)-piperidin-4-yl]-furo[2,3-c]pyridine

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Chemical Property of 5-(2-fluoro-4-methanesulfonyl-phenyl)-2-[1-(1-trifluoromethyl-cyclopropylmethyl)-piperidin-4-yl]-furo[2,3-c]pyridine

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Technology Process of 5-(2-fluoro-4-methanesulfonyl-phenyl)-2-[1-(1-trifluoromethyl-cyclopropylmethyl)-piperidin-4-yl]-furo[2,3-c]pyridine

There total 5 articles about 5-(2-fluoro-4-methanesulfonyl-phenyl)-2-[1-(1-trifluoromethyl-cyclopropylmethyl)-piperidin-4-yl]-furo[2,3-c]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1262400-04-3
methanesulfonic acid (1-(trifluoromethyl)cyclopropyl)methyl ester

: 1451163-58-8
5-(2-fluoro-4-methanesulfonyl-phenyl)-2-piperidin-4-yl-furo[2,3-c]pyridine

: 1451163-44-2
5-(2-fluoro-4-methanesulfonyl-phenyl)-2-[1-(1-trifluoromethyl-cyclopropylmethyl)-piperidin-4-yl]-furo[2,3-c]pyridine

Guidance literature:: With potassium carbonate; potassium iodide; In 1-methyl-pyrrolidin-2-one; at 100 ℃; for 4h;

Reference yield:

: 1382136-55-1
4-(5-chloro-furo[2,3-c]pyridin-2-yl)-piperidine-1-carboxylic acid tert-butyl ester

: 1451163-44-2
5-(2-fluoro-4-methanesulfonyl-phenyl)-2-[1-(1-trifluoromethyl-cyclopropylmethyl)-piperidin-4-yl]-furo[2,3-c]pyridine

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / water; 1,4-dioxane; methanol / 2 h / Reflux; Inert atmosphere

2.1: trifluoroacetic acid / dichloromethane / 20 °C

2.2: 0.08 h

3.1: potassium carbonate; potassium iodide / 1-methyl-pyrrolidin-2-one / 4 h / 100 °C

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate; potassium carbonate; trifluoroacetic acid; potassium iodide; In 1,4-dioxane; 1-methyl-pyrrolidin-2-one; methanol; dichloromethane; water;

Reference yield:

: 1382136-84-6
4-[5-(2-fluoro-4-methanesulfonyl-phenyl)-furo[2,3-c]pyridin-2-yl]-piperidine-1-carboxylic acid tert-butyl ester

: 1451163-44-2
5-(2-fluoro-4-methanesulfonyl-phenyl)-2-[1-(1-trifluoromethyl-cyclopropylmethyl)-piperidin-4-yl]-furo[2,3-c]pyridine

Guidance literature:: Multi-step reaction with 2 steps

1.1: trifluoroacetic acid / dichloromethane / 20 °C

1.2: 0.08 h

2.1: potassium carbonate; potassium iodide / 1-methyl-pyrrolidin-2-one / 4 h / 100 °C

With potassium carbonate; trifluoroacetic acid; potassium iodide; In 1-methyl-pyrrolidin-2-one; dichloromethane;