(3S,5S)-7-[5-(4-Fluoro-phenyl)-3-isopropyl-1-phenyl-1H-pyrazol-4-yl]-3,5-dihydroxy-heptanoic acid methyl ester

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Chemical Name:(3S,5S)-7-[5-(4-Fluoro-phenyl)-3-isopropyl-1-phenyl-1H-pyrazol-4-yl]-3,5-dihydroxy-heptanoic acid methyl ester
CAS No.:124288-14-8
Molecular Formula:C₂₆H₃₁FN₂O₄
Molecular Weight:454.542
Hs Code.:

Synonyms:(3S,5S)-7-[5-(4-Fluoro-phenyl)-3-isopropyl-1-phenyl-1H-pyrazol-4-yl]-3,5-dihydroxy-heptanoic acid methyl ester

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Chemical Property of (3S,5S)-7-[5-(4-Fluoro-phenyl)-3-isopropyl-1-phenyl-1H-pyrazol-4-yl]-3,5-dihydroxy-heptanoic acid methyl ester

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Technology Process of (3S,5S)-7-[5-(4-Fluoro-phenyl)-3-isopropyl-1-phenyl-1H-pyrazol-4-yl]-3,5-dihydroxy-heptanoic acid methyl ester

There total 5 articles about (3S,5S)-7-[5-(4-Fluoro-phenyl)-3-isopropyl-1-phenyl-1H-pyrazol-4-yl]-3,5-dihydroxy-heptanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 124288-11-5
6-{2-[5-(4-Fluoro-phenyl)-3-isopropyl-1-phenyl-1H-pyrazol-4-yl]-ethyl}-dihydro-pyran-2,4-dione

: 124288-14-8
(3S,5S)-7-[5-(4-Fluoro-phenyl)-3-isopropyl-1-phenyl-1H-pyrazol-4-yl]-3,5-dihydroxy-heptanoic acid methyl ester

: 116645-09-1,124288-04-6,124288-13-7
(+/-)-cis-6-<2-<5-(4-fluorophenyl)-3-(1-methylethyl)-1-phenyl-1H-pyrazol-4-yl>ethyl>tetrahydro-4-hydroxy-2H-pyran-2-one

: 116645-09-1,124288-04-6,124288-13-7
(+/-)-trans-6-<2-<5-(4-fluorophenyl)-3-(1-methylethyl)-1-phenyl-1H-pyrazol-4-yl>ethyl>tetrahydro-4-hydroxy-2H-pyran-2-one

Guidance literature:: With hydrogen; Ru-carbon; In methanol; for 120h; under 760 Torr; Yields of byproduct given; Ambient temperature;
DOI:10.1021/jm00163a006

Reference yield:

: 114433-94-2
1-(4-Fluorophenyl)-3-isopropylpropan-1,3-dione

: 124288-14-8
(3S,5S)-7-[5-(4-Fluoro-phenyl)-3-isopropyl-1-phenyl-1H-pyrazol-4-yl]-3,5-dihydroxy-heptanoic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) NaH, 2.) NaI / 1.) DMF, 2.) 80 to 90 deg C, 36 h

2: 40 percent / ethanol / 120 h / Heating

3: 65 percent / 70percent aq. acetic acid / 48 h / Heating

5: H₂ / 10percent Ru/C / methanol / 120 h / 760 Torr / Ambient temperature

With hydrogen; sodium hydride; acetic acid; sodium iodide; Ru-carbon; In methanol; ethanol;
DOI:10.1021/jm00163a006

Reference yield:

: 116645-13-7
2-<2-(1,3-dioxolan-2-yl)ethyl>-1-(4-fluorophenyl)-4-methyl-1,3-pentanedione

: 124288-14-8
(3S,5S)-7-[5-(4-Fluoro-phenyl)-3-isopropyl-1-phenyl-1H-pyrazol-4-yl]-3,5-dihydroxy-heptanoic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 40 percent / ethanol / 120 h / Heating

2: 65 percent / 70percent aq. acetic acid / 48 h / Heating

4: H₂ / 10percent Ru/C / methanol / 120 h / 760 Torr / Ambient temperature

With hydrogen; acetic acid; Ru-carbon; In methanol; ethanol;
DOI:10.1021/jm00163a006