[5-methyl-5-(thiophen-2-yl)-2-(trifluoromethyl)-4,5-dihydrofuran-3-yl](phenyl)methanone

Base Information

Chemical Name:[5-methyl-5-(thiophen-2-yl)-2-(trifluoromethyl)-4,5-dihydrofuran-3-yl](phenyl)methanone
CAS No.:1343477-40-6
Molecular Formula:C₁₇H₁₃F₃O₂S
Molecular Weight:338.35
Hs Code.:

Synonyms:[5-methyl-5-(thiophen-2-yl)-2-(trifluoromethyl)-4,5-dihydrofuran-3-yl](phenyl)methanone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of [5-methyl-5-(thiophen-2-yl)-2-(trifluoromethyl)-4,5-dihydrofuran-3-yl](phenyl)methanone

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Technology Process of [5-methyl-5-(thiophen-2-yl)-2-(trifluoromethyl)-4,5-dihydrofuran-3-yl](phenyl)methanone

There total 2 articles about [5-methyl-5-(thiophen-2-yl)-2-(trifluoromethyl)-4,5-dihydrofuran-3-yl](phenyl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 30616-73-0
2-isopropenylthiophene

: 326-06-7
1-Phenyl-4,4,4-trifluorobutane-1,3-dione

: 1343477-40-6
[5-methyl-5-(thiophen-2-yl)-2-(trifluoromethyl)-4,5-dihydrofuran-3-yl](phenyl)methanone

: 1343477-39-3
2,2,2-trifluoro-1-[5-methyl-2-phenyl-5-(thiophen-2-yl)-4,5-dihydrofuran-3-yl]ethanone

Guidance literature:: With manganese(III) triacetate dihydrate; acetic acid; at 60 - 100 ℃; Inert atmosphere;
DOI:10.1016/j.tet.2011.08.098

Reference yield:

: 88-15-3,97511-16-5
2-Acetylthiophene

: 1343477-40-6
[5-methyl-5-(thiophen-2-yl)-2-(trifluoromethyl)-4,5-dihydrofuran-3-yl](phenyl)methanone

: 1343477-39-3
2,2,2-trifluoro-1-[5-methyl-2-phenyl-5-(thiophen-2-yl)-4,5-dihydrofuran-3-yl]ethanone

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 1 h / 60 °C

1.2: 5 °C / Reflux

2.1: manganese(III) triacetate dihydrate; acetic acid / 60 - 100 °C / Inert atmosphere

With manganese(III) triacetate dihydrate; sodium hydride; acetic acid; In tetrahydrofuran; mineral oil;
DOI:10.1016/j.tet.2011.08.098