(-)-4-(4-chloro-phenoxy)-N-(1-hydroxy-2-oxo-2,3,4,7-tetrahydro-1H-azepin-3-yl)-N-(2-morpholin-4-yl-ethyl)-benzenesulfonamide

Base Information

Chemical Name:(-)-4-(4-chloro-phenoxy)-N-(1-hydroxy-2-oxo-2,3,4,7-tetrahydro-1H-azepin-3-yl)-N-(2-morpholin-4-yl-ethyl)-benzenesulfonamide
CAS No.:1020104-47-5
Molecular Formula:C₂₄H₂₈ClN₃O₆S
Molecular Weight:522.022
Hs Code.:

Synonyms:(-)-4-(4-chloro-phenoxy)-N-(1-hydroxy-2-oxo-2,3,4,7-tetrahydro-1H-azepin-3-yl)-N-(2-morpholin-4-yl-ethyl)-benzenesulfonamide

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Chemical Property of (-)-4-(4-chloro-phenoxy)-N-(1-hydroxy-2-oxo-2,3,4,7-tetrahydro-1H-azepin-3-yl)-N-(2-morpholin-4-yl-ethyl)-benzenesulfonamide

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Technology Process of (-)-4-(4-chloro-phenoxy)-N-(1-hydroxy-2-oxo-2,3,4,7-tetrahydro-1H-azepin-3-yl)-N-(2-morpholin-4-yl-ethyl)-benzenesulfonamide

There total 5 articles about (-)-4-(4-chloro-phenoxy)-N-(1-hydroxy-2-oxo-2,3,4,7-tetrahydro-1H-azepin-3-yl)-N-(2-morpholin-4-yl-ethyl)-benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1020104-48-6
(-)-N-(1-benzyloxy-2-oxo-2,3,4,7-tetrahydro-1H-azepin-3-yl)-4-(4-chloro-phenoxy)-N-(2-morpholin-4-yl-ethyl)-benzenesulfonamide

: 1020104-47-5
(-)-4-(4-chloro-phenoxy)-N-(1-hydroxy-2-oxo-2,3,4,7-tetrahydro-1H-azepin-3-yl)-N-(2-morpholin-4-yl-ethyl)-benzenesulfonamide

Guidance literature:: With methanesulfonic acid; at 20 ℃; for 20h;

Reference yield:

: 1020104-29-3
(+)-[1-(allyl-benzyloxy-carbamoyl)-but-3-(R)-enyl]-carbamic acid tert-butyl ester

: 1020104-47-5
(-)-4-(4-chloro-phenoxy)-N-(1-hydroxy-2-oxo-2,3,4,7-tetrahydro-1H-azepin-3-yl)-N-(2-morpholin-4-yl-ethyl)-benzenesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride / dichloromethane / 8 h / 20 °C

2: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

3: pyridine / dichloromethane / 120 h / 20 °C

4: caesium carbonate / dimethyl sulfoxide / 1 h / 50 °C

5: methanesulfonic acid / 20 h / 20 °C

With pyridine; tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; methanesulfonic acid; caesium carbonate; trifluoroacetic acid; In dichloromethane; dimethyl sulfoxide;
DOI:10.1016/j.bmcl.2011.08.068

Reference yield:

: 1020104-31-7
(-)-(1-benzyloxy-2-oxo-2,3,4,7-tetrahydro-1H-azepin-3-R-yl)-carbamic acid tert-butyl ester

: 1020104-47-5
(-)-4-(4-chloro-phenoxy)-N-(1-hydroxy-2-oxo-2,3,4,7-tetrahydro-1H-azepin-3-yl)-N-(2-morpholin-4-yl-ethyl)-benzenesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

2: pyridine / dichloromethane / 120 h / 20 °C

3: caesium carbonate / dimethyl sulfoxide / 1 h / 50 °C

4: methanesulfonic acid / 20 h / 20 °C

With pyridine; methanesulfonic acid; caesium carbonate; trifluoroacetic acid; In dichloromethane; dimethyl sulfoxide;
DOI:10.1016/j.bmcl.2011.08.068