N-(3-(5-methyl-2-(3-(prop-2-ynyloxy)phenylamino)pyrimidin-4-ylamino)phenyl)acrylamide

Base Information

Chemical Name:N-(3-(5-methyl-2-(3-(prop-2-ynyloxy)phenylamino)pyrimidin-4-ylamino)phenyl)acrylamide
CAS No.:1202756-20-4
Molecular Formula:C₂₃H₂₁N₅O₂
Molecular Weight:399.452
Hs Code.:

Synonyms:N-(3-(5-methyl-2-(3-(prop-2-ynyloxy)phenylamino)pyrimidin-4-ylamino)phenyl)acrylamide

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Chemical Property of N-(3-(5-methyl-2-(3-(prop-2-ynyloxy)phenylamino)pyrimidin-4-ylamino)phenyl)acrylamide

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Technology Process of N-(3-(5-methyl-2-(3-(prop-2-ynyloxy)phenylamino)pyrimidin-4-ylamino)phenyl)acrylamide

There total 6 articles about N-(3-(5-methyl-2-(3-(prop-2-ynyloxy)phenylamino)pyrimidin-4-ylamino)phenyl)acrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 18.0%

: 1202759-78-1
C₂₀H₁₉N₅O

: 814-68-6,25189-84-8
acryloyl chloride

: 1202756-20-4
N-(3-(5-methyl-2-(3-(prop-2-ynyloxy)phenylamino)pyrimidin-4-ylamino)phenyl)acrylamide

Guidance literature:: C₂₀H₁₉N₅O; acryloyl chloride; In 1-methyl-pyrrolidin-2-one; at 0 - 20 ℃; for 1.66667h;

With sodium hydrogencarbonate; In 1-methyl-pyrrolidin-2-one;

Reference yield:

: 1780-31-0
2,6-dichloro-5-methylpyrimidine

: 1202756-20-4
N-(3-(5-methyl-2-(3-(prop-2-ynyloxy)phenylamino)pyrimidin-4-ylamino)phenyl)acrylamide

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine / butan-1-ol / 0.5 h / 120 °C / Microwave irradiation

2: hydrogenchloride / ethanol; water / 2 h / 120 °C

3: 1-methyl-pyrrolidin-2-one / 1.67 h / 0 - 20 °C

With hydrogenchloride; N-ethyl-N,N-diisopropylamine; In 1-methyl-pyrrolidin-2-one; ethanol; water; butan-1-ol;

Reference yield:

: 554-84-7
meta-nitrophenol

: 1202756-20-4
N-(3-(5-methyl-2-(3-(prop-2-ynyloxy)phenylamino)pyrimidin-4-ylamino)phenyl)acrylamide

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / acetonitrile / 8 h / Reflux

2: iron; ammonium chloride / methanol; water / 4 h / 80 °C

3: hydrogenchloride / ethanol; water / 2 h / 120 °C

4: 1-methyl-pyrrolidin-2-one / 1.67 h / 0 - 20 °C

With hydrogenchloride; iron; potassium carbonate; ammonium chloride; In 1-methyl-pyrrolidin-2-one; methanol; ethanol; water; acetonitrile;