(E)-3-(4-bromophenyl)-4,4,4-trifluoro-1-phenyl-2-buten-1-one

Base Information

• Chemical Name: (E)-3-(4-bromophenyl)-4,4,4-trifluoro-1-phenyl-2-buten-1-one
• CAS No.: 1245905-80-9
• Molecular Formula: C₁₆H₁₀BrF₃O
• Molecular Weight: 355.154
• Mol file: 1245905-80-9.mol

Synonyms:(E)-3-(4-bromophenyl)-4,4,4-trifluoro-1-phenyl-2-buten-1-one

Chemical Property of (E)-3-(4-bromophenyl)-4,4,4-trifluoro-1-phenyl-2-buten-1-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-3-(4-bromophenyl)-4,4,4-trifluoro-1-phenyl-2-buten-1-one

There total 2 articles about (E)-3-(4-bromophenyl)-4,4,4-trifluoro-1-phenyl-2-buten-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

4'-bromo-2,2,2-trifluoroacetophenone (16184-89-7) + (2-oxo-2-phenylethyl)-triphenylphosphonium chloride (1678-18-8) → (E)-3-(4-bromophenyl)-4,4,4-trifluoro-1-phenyl-2-buten-1-one (1245905-80-9)

Guidance literature:

With triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide; at 80 ℃; for 3h; Inert atmosphere;

DOI:10.1021/acs.orglett.6b01494

Reference yield: 94.0%

4'-bromo-2,2,2-trifluoroacetophenone (16184-89-7) + triphenylphenacylphosphonium bromide (6048-29-9) → (E)-3-(4-bromophenyl)-4,4,4-trifluoro-1-phenyl-2-buten-1-one (1245905-80-9)

Guidance literature:

With triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide; at 0 - 80 ℃;

DOI:10.1002/anie.201200827

Reference yield: 99.0%

(E)-3-(4-bromophenyl)-4,4,4-trifluoro-1-phenyl-2-buten-1-one (1245905-80-9) → (R)-5-(4-bromophenyl)-5-(trifluoromethyl)-4,5-dihydro-3-phenylisoxazole (1245905-64-9)

Guidance literature:

With cesiumhydroxide monohydrate; N-[3,5-bis(trifluoromethyl)benzyl]quinidinium bromide; hydroxylamine; In chloroform; water; at -30 ℃; for 11h; optical yield given as %ee; enantioselective reaction; Inert atmosphere;

DOI:10.1002/anie.201002065

upstream raw materials:

4'-bromo-2,2,2-trifluoroacetophenone

triphenylphenacylphosphonium bromide

(2-oxo-2-phenylethyl)-triphenylphosphonium chloride

Downstream raw materials:

(R)-5-(4-bromophenyl)-5-(trifluoromethyl)-4,5-dihydro-3-phenylisoxazole

(R)-2-(4-bromophenyl)-4-oxo-4-phenyl-2-(trifluoromethyl)butanenitrile

(R)-3-(4-bromoephenyl)-4,4,4-trifluoro-1-phenylbutan-1-one

(E)-3-(4-bromophenyl)-4,4,4-trifluoro-1-phenyl-2-buten-1-ol