Pyridazine-3,6-dicarboxylic acid bis-[((R)-1-hydroxymethyl-2-phenyl-ethyl)-amide]

Base Information

Chemical Name:Pyridazine-3,6-dicarboxylic acid bis-[((R)-1-hydroxymethyl-2-phenyl-ethyl)-amide]
CAS No.:205885-15-0
Molecular Formula:C₂₄H₂₆N₄O₄
Molecular Weight:434.495
Hs Code.:

Synonyms:Pyridazine-3,6-dicarboxylic acid bis-[((R)-1-hydroxymethyl-2-phenyl-ethyl)-amide]

Suppliers and Price of Pyridazine-3,6-dicarboxylic acid bis-[((R)-1-hydroxymethyl-2-phenyl-ethyl)-amide]

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Pyridazine-3,6-dicarboxylic acid bis-[((R)-1-hydroxymethyl-2-phenyl-ethyl)-amide]

Chemical Property:

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Technology Process of Pyridazine-3,6-dicarboxylic acid bis-[((R)-1-hydroxymethyl-2-phenyl-ethyl)-amide]

There total 2 articles about Pyridazine-3,6-dicarboxylic acid bis-[((R)-1-hydroxymethyl-2-phenyl-ethyl)-amide] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 5267-64-1
(R)-2-amino-3-phenylpropanol

: 187826-59-1
pyridazine-3,6-dicarbonyl dichloride

: 205885-15-0
Pyridazine-3,6-dicarboxylic acid bis-[((R)-1-hydroxymethyl-2-phenyl-ethyl)-amide]

Guidance literature:: With triethylamine; In chloroform; Ambient temperature;
DOI:10.1002/hlca.19980810304

Reference yield:

: 57266-70-3
pyridazine-3,6-dicarboxylic acid

: 205885-15-0
Pyridazine-3,6-dicarboxylic acid bis-[((R)-1-hydroxymethyl-2-phenyl-ethyl)-amide]

Guidance literature:: Multi-step reaction with 2 steps

1: 89 percent / oxalyl chloride, DMF / benzene / 0.5 h / Heating

2: 91 percent / Et₃N / CHCl₃ / Ambient temperature

With oxalyl dichloride; triethylamine; N,N-dimethyl-formamide; In chloroform; benzene;
DOI:10.1002/hlca.19980810304