6-chloro-9-<5-O-benzoyl-2-deoxy-2-<(benzoyloxy)methyl>-3-O-formyl-β-D-ribofuranosyl>-9H-purine

Base Information

Chemical Name:6-chloro-9-<5-O-benzoyl-2-deoxy-2-<(benzoyloxy)methyl>-3-O-formyl-β-D-ribofuranosyl>-9H-purine
CAS No.:130469-44-2
Molecular Formula:C₂₆H₂₁ClN₄O₇
Molecular Weight:536.928
Hs Code.:

Synonyms:6-chloro-9-<5-O-benzoyl-2-deoxy-2-<(benzoyloxy)methyl>-3-O-formyl-β-D-ribofuranosyl>-9H-purine

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Chemical Property of 6-chloro-9-<5-O-benzoyl-2-deoxy-2-<(benzoyloxy)methyl>-3-O-formyl-β-D-ribofuranosyl>-9H-purine

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Technology Process of 6-chloro-9-<5-O-benzoyl-2-deoxy-2-<(benzoyloxy)methyl>-3-O-formyl-β-D-ribofuranosyl>-9H-purine

There total 5 articles about 6-chloro-9-<5-O-benzoyl-2-deoxy-2-<(benzoyloxy)methyl>-3-O-formyl-β-D-ribofuranosyl>-9H-purine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 32865-86-4
6-chloro-9-trimethylsilylpurine

: 1032414-32-6
5-O-benzoyl-2-deoxy-2-<(benzoyloxy)methyl>-3-O-formyl-1-O-acetyl-D-ribofuranose

: 130469-44-2
6-chloro-9-<5-O-benzoyl-2-deoxy-2-<(benzoyloxy)methyl>-3-O-formyl-β-D-ribofuranosyl>-9H-purine

Guidance literature:: With trimethylsilyl trifluoromethanesulfonate; In acetonitrile; for 0.333333h; Ambient temperature;
DOI:10.1021/jm00105a054

Reference yield:

: 69832-48-0
((3aR,5S,6R,6aR)-tetrahydro-2,2-dimethyl-5-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)furo[2,3-d][1,3]dioxol-6-yl)methanol

: 130469-44-2
6-chloro-9-<5-O-benzoyl-2-deoxy-2-<(benzoyloxy)methyl>-3-O-formyl-β-D-ribofuranosyl>-9H-purine

Guidance literature:: Multi-step reaction with 7 steps

1: 95 percent / pyridine

2: 1.47 g / 0.06 N aq. HCl / methanol / 1 h / 55 °C

3: pyridine / CH₂Cl₂ / 1.5 h / -30 °C

4: 0.95 g / BCl₃ / CH₂Cl₂ / 0.03 h

5: KIO₄ / H₂O; ethanol / 19 h / Ambient temperature

6: 70 percent / pyridine / 20 h / Ambient temperature

7: 66 percent / trimethylsilyl triflate / acetonitrile / 0.33 h / Ambient temperature

With pyridine; hydrogenchloride; potassium metaperiodate; trimethylsilyl trifluoromethanesulfonate; boron trichloride; In methanol; ethanol; dichloromethane; water; acetonitrile;
DOI:10.1021/jm00105a054

Reference yield:

: 130469-40-8
3-deoxy-3-<(benzoyloxy)methyl>-1,2:5,6-di-O-isopropylidene-α-D-allofuranose

: 130469-44-2
6-chloro-9-<5-O-benzoyl-2-deoxy-2-<(benzoyloxy)methyl>-3-O-formyl-β-D-ribofuranosyl>-9H-purine

Guidance literature:: Multi-step reaction with 6 steps

1: 1.47 g / 0.06 N aq. HCl / methanol / 1 h / 55 °C

2: pyridine / CH₂Cl₂ / 1.5 h / -30 °C

3: 0.95 g / BCl₃ / CH₂Cl₂ / 0.03 h

4: KIO₄ / H₂O; ethanol / 19 h / Ambient temperature

5: 70 percent / pyridine / 20 h / Ambient temperature

6: 66 percent / trimethylsilyl triflate / acetonitrile / 0.33 h / Ambient temperature

With pyridine; hydrogenchloride; potassium metaperiodate; trimethylsilyl trifluoromethanesulfonate; boron trichloride; In methanol; ethanol; dichloromethane; water; acetonitrile;
DOI:10.1021/jm00105a054