4-[bis-(2-chloro-ethyl)-amino]-L-phenylalanine ethyl ester; hydrochloride

Base Information

• Chemical Name: 4-[bis-(2-chloro-ethyl)-amino]-L-phenylalanine ethyl ester; hydrochloride
• CAS No.: 112117-81-4
• Molecular Formula: C₁₅H₂₂Cl₂N₂O₂*ClH
• Molecular Weight: 369.719

Synonyms:4-[bis-(2-chloro-ethyl)-amino]-L-phenylalanine ethyl ester; hydrochloride

Chemical Property of 4-[bis-(2-chloro-ethyl)-amino]-L-phenylalanine ethyl ester; hydrochloride

Chemical Property:

Purity/Quality:

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Technology Process of 4-[bis-(2-chloro-ethyl)-amino]-L-phenylalanine ethyl ester; hydrochloride

There total 1 articles about 4-[bis-(2-chloro-ethyl)-amino]-L-phenylalanine ethyl ester; hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-phthalimido-4-(bis-2-chloroethyl)amino-L-phenylalanine ethyl ester (792864-20-1,93942-39-3) → 4-[bis-(2-chloro-ethyl)-amino]-L-phenylalanine ethyl ester; hydrochloride (112117-81-4)

Guidance literature:

N-phthaloyl-4-[bis(2-dichloroethyl)amino]-phenylalanine ethyl ester; With hydrogenchloride; water; at 50 ℃; for 7h; Industry scale; Reflux;

With ammonium hydroxide; In water; pH=1.5;

Reference yield:

4-[bis-(2-chloro-ethyl)-amino]-L-phenylalanine ethyl ester; hydrochloride (112117-81-4) → N-Alanyl-3-(4--phenyl)-α-alanin-ethylester (103773-22-4)

Guidance literature:

Multi-step reaction with 2 steps

1: (i) ClCO₂iBu, Et₃N, (ii) /BRN= 7191042/, Et₃N

2: HCl / ethanol

With hydrogenchloride; In ethanol;

DOI:10.1039/jr9600003658

Reference yield:

4-[bis-(2-chloro-ethyl)-amino]-L-phenylalanine ethyl ester; hydrochloride (112117-81-4) → D-Ala-Mel-OEt (103773-22-4)

Guidance literature:

Multi-step reaction with 2 steps

1: (i) ClCO₂iBu, Et₃N, (ii) /BRN= 7191042/, Et₃N

2: HCl / ethanol

With hydrogenchloride; In ethanol;

DOI:10.1039/jr9600003658

upstream raw materials:

N-phthalimido-4-(bis-2-chloroethyl)amino-L-phenylalanine ethyl ester

Downstream raw materials:

N-Succinamino-p--L-phenylalanin-ethylester

Z-L-Leu-Mel-OEt

Z-D-Ala-Mel-OEt

Z-L-Ala-Mel-OEt

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