Technology Process of 5-<(tert-butyloxy)carbonyl>-3-(5-cyclopropyl-1,2,4-oxadiazol-3-yl)-6-fluoro-4,5-dihydroimidazo<1,5-a>quinoxaline
There total 1 articles about 5-<(tert-butyloxy)carbonyl>-3-(5-cyclopropyl-1,2,4-oxadiazol-3-yl)-6-fluoro-4,5-dihydroimidazo<1,5-a>quinoxaline which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1: SOCl2 / 2 h / Heating
2: 30percent aq. NH4OH / CH2Cl2
3: 62 percent / Pb(OAc)4 / 1.5 h / Heating
4: 73 percent / potassium tert-butoxide / tetrahydrofuran / 2 h
5: 1.) H2, 2.) p-toluenesulfonic acid / 1.) 10percent Pd/C / 1.) MeOH, 37 psi, 1 h, 2.) MeOH, 80 deg C, 1 h
6: 1.) potassium tert-butoxide, diethyl chlorophosphate / 1.) THF, a) -78 deg C, 15 min, b) from -78 deg C to RT, 45 min, 2.) THF, a) -78 deg C, 2 h, b) from -78 deg C to RT, 30 min
With
lead(IV) acetate; ammonium hydroxide; thionyl chloride; potassium tert-butylate; hydrogen; diethyl chlorophosphate; toluene-4-sulfonic acid;
palladium on activated charcoal;
In
tetrahydrofuran; dichloromethane;
DOI:10.1021/jm00032a008
- Guidance literature:
-
Multi-step reaction with 2 steps
1: methanolic HCl / Ambient temperature
2: 82 percent / (dimethylamino)pyridine, diisopropylethylamine / tetrahydrofuran; dimethylformamide
With
hydrogenchloride; dmap; N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jm00032a008
