2-FLUOROPHENETHYLAMINE

Base Information

• Chemical Name: 2-FLUOROPHENETHYLAMINE
• CAS No.: 52721-69-4
• Molecular Formula: C8H10FN
• Molecular Weight: 139.173
• Hs Code.: 29214990
• Mol file: 52721-69-4.mol

Synonyms:2-(2-Fluorophenyl)ethanamine;2-(2-Fluorophenyl)ethylamine;2-Fluorobenzeneethanamine;2-Fluorophenethylamine;o-Fluorophenethylamine;o-Fluorophenylethylamine;

Chemical Property of 2-FLUOROPHENETHYLAMINE

Chemical Property:

• Appearance/Colour: clear pale yellow to slightly pink liquid
• Vapor Pressure: 0.0333mmHg at 25°C
• Refractive Index: n20/D 1.51(lit.)
• Boiling Point: 242.8 °C at 760 mmHg
• PKA: 9.47±0.10(Predicted)
• Flash Point: 77.2 °C
• PSA: 26.02000
• Density: 1.069 g/cm³
• LogP: 2.02720
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

2-(2-Fluorophenyl)ethylamine >98.0%(GC)(T) ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-Fluorophenethylamine may be used in the synthesis of ethyl 2-cyano-3-(N-2-fluorophenethylamino)-3-methythioacrylate. It may be used for the derivatization of methoxybenzaldehyde polystyrene resin.

Technology Process of 2-FLUOROPHENETHYLAMINE

There total 9 articles about 2-FLUOROPHENETHYLAMINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-fluoro-2-(2-nitro-vinyl)-benzene (399-25-7) → [2-(2-fluorophenyl)ethyl]amine (52721-69-4)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether;

DOI:10.1021/jm00094a006

Reference yield:

2-fluorostyrene (394-46-7) → [2-(2-fluorophenyl)ethyl]amine (52721-69-4)

Guidance literature:

With D-Glucose; ammonia; oxygen; In aq. phosphate buffer; at 30 ℃; for 10h; regioselective reaction; Green chemistry;

DOI:10.1021/acscatal.7b01464

Reference yield:

2-Fluorobenzaldehyde (446-52-6) → [2-(2-fluorophenyl)ethyl]amine (52721-69-4)

Guidance literature:

Multi-step reaction with 2 steps

2: LiAlH₄ / diethyl ether

With lithium aluminium tetrahydride; In diethyl ether;

DOI:10.1021/jm00094a006

upstream raw materials:

1-fluoro-2-(2-nitro-vinyl)-benzene

2-(2-fluorophenyl)ethanol

2-Fluorobenzaldehyde

2-fluorostyrene

Downstream raw materials:

N⁶-<2-(fluorophenyl)ethyl>adenosine

N-(o-fluorophenethyl)-N'-(o-fluorophenethyl)-thiourea

[1-((3aR,5R,6S,6aR)-6-Benzyloxy-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-5-yl)-meth-(E)-ylidene]-[2-(2-fluoro-phenyl)-ethyl]-amine

2,7-di-tert-butyl-5-[(2-fluorophenyl)ethylcarbamoyl]-9,9-dimethyl-9H-xanthene-4-carboxylic acid phenyl ester

Refernces

• 1、 Ravichandran, Veerasamy,Shalini, Sivadasan,Kumar, Krishnan Suresh,Rajak, Harish,Agrawal, Ram Kishore. "Design, synthesis and evaluation of thiourea derivatives as antimicrobial and antiviral agents". . p. 618 - 624. Retrieved 2019/06/25.
• 2、 -. "Tetracyclic benzimidazole derivatives and combinatorial libraries thereof". . . Retrieved 2008/06/13.