(S)-N-(6,7-dihydro-2-nitro-5H-imidazo[2,1-b][1,3]oxazin-6-yl)-3-(4-(4-(trifluoromethoxy)phenoxy)piperidin-1-yl) propanamide

Base Information

Chemical Name:(S)-N-(6,7-dihydro-2-nitro-5H-imidazo[2,1-b][1,3]oxazin-6-yl)-3-(4-(4-(trifluoromethoxy)phenoxy)piperidin-1-yl) propanamide
CAS No.:1346017-61-5
Molecular Formula:C₂₁H₂₄F₃N₅O₆
Molecular Weight:499.447
Hs Code.:

Synonyms:(S)-N-(6,7-dihydro-2-nitro-5H-imidazo[2,1-b][1,3]oxazin-6-yl)-3-(4-(4-(trifluoromethoxy)phenoxy)piperidin-1-yl) propanamide

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Chemical Property of (S)-N-(6,7-dihydro-2-nitro-5H-imidazo[2,1-b][1,3]oxazin-6-yl)-3-(4-(4-(trifluoromethoxy)phenoxy)piperidin-1-yl) propanamide

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Technology Process of (S)-N-(6,7-dihydro-2-nitro-5H-imidazo[2,1-b][1,3]oxazin-6-yl)-3-(4-(4-(trifluoromethoxy)phenoxy)piperidin-1-yl) propanamide

There total 9 articles about (S)-N-(6,7-dihydro-2-nitro-5H-imidazo[2,1-b][1,3]oxazin-6-yl)-3-(4-(4-(trifluoromethoxy)phenoxy)piperidin-1-yl) propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 23.0%

: 187235-66-1
(S)-2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine-6-amine

: 1346017-81-9
3-(4-(4-(trifluoromethoxy)phenoxy)piperidin-1-yl)propionyl chloride

: 1346017-61-5
(S)-N-(6,7-dihydro-2-nitro-5H-imidazo[2,1-b][1,3]oxazin-6-yl)-3-(4-(4-(trifluoromethoxy)phenoxy)piperidin-1-yl) propanamide

Guidance literature:: With triethylamine; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 3h; Inert atmosphere;

Reference yield:

: 1346017-85-3
3-(4-(4-(trifluoromethoxy)phenoxy)piperidin-1-yl)propionic acid

: 1346017-61-5
(S)-N-(6,7-dihydro-2-nitro-5H-imidazo[2,1-b][1,3]oxazin-6-yl)-3-(4-(4-(trifluoromethoxy)phenoxy)piperidin-1-yl) propanamide

Guidance literature:: Multi-step reaction with 2 steps

1: oxalyl dichloride; N,N-dimethyl-formamide / toluene / 20 °C

2: triethylamine / N,N-dimethyl-formamide / 3 h / 0 - 20 °C / Inert atmosphere

With oxalyl dichloride; triethylamine; N,N-dimethyl-formamide; In N,N-dimethyl-formamide; toluene;

Reference yield:

: 828-27-3
4-Trifluoromethoxyphenol

: 1346017-61-5
(S)-N-(6,7-dihydro-2-nitro-5H-imidazo[2,1-b][1,3]oxazin-6-yl)-3-(4-(4-(trifluoromethoxy)phenoxy)piperidin-1-yl) propanamide

Guidance literature:: Multi-step reaction with 6 steps

1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran; water / 20 °C

2: trifluoroacetic acid; water / 3 h / 20 °C

3: potassium carbonate / acetonitrile / 3 h / Reflux

4: water; sodium hydroxide / tetrahydrofuran / 3 h / 0 - 20 °C

5: oxalyl dichloride; N,N-dimethyl-formamide / toluene / 20 °C

6: triethylamine / N,N-dimethyl-formamide / 3 h / 0 - 20 °C / Inert atmosphere

With oxalyl dichloride; di-isopropyl azodicarboxylate; water; potassium carbonate; triethylamine; N,N-dimethyl-formamide; triphenylphosphine; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; water; N,N-dimethyl-formamide; toluene; acetonitrile;