2-{4-[2-(1H-Tetrazol-5-ylmethyl)-cyclopentylmethyl]-phenoxymethyl}-quinoline

Base Information

Chemical Name:2-{4-[2-(1H-Tetrazol-5-ylmethyl)-cyclopentylmethyl]-phenoxymethyl}-quinoline
CAS No.:304024-18-8
Molecular Formula:C₂₄H₂₅N₅O
Molecular Weight:399.495
Hs Code.:

Synonyms:2-{4-[2-(1H-Tetrazol-5-ylmethyl)-cyclopentylmethyl]-phenoxymethyl}-quinoline

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Chemical Property of 2-{4-[2-(1H-Tetrazol-5-ylmethyl)-cyclopentylmethyl]-phenoxymethyl}-quinoline

Chemical Property:

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Technology Process of 2-{4-[2-(1H-Tetrazol-5-ylmethyl)-cyclopentylmethyl]-phenoxymethyl}-quinoline

There total 6 articles about 2-{4-[2-(1H-Tetrazol-5-ylmethyl)-cyclopentylmethyl]-phenoxymethyl}-quinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 129650-19-7,129650-24-4
2-<<4-(quinolin-2-ylmethoxy)phenyl>methyl>cyclopentaneacetonitrile

: 304024-18-8
2-{4-[2-(1H-Tetrazol-5-ylmethyl)-cyclopentylmethyl]-phenoxymethyl}-quinoline

Guidance literature:: With sodium azide; ammonium chloride; In N,N-dimethyl-formamide; at 110 - 120 ℃;
DOI:10.1021/jm00172a024

Reference yield:

: 51004-14-9
2-(2-oxocyclopentyl)acetonitrile

: 304024-18-8
2-{4-[2-(1H-Tetrazol-5-ylmethyl)-cyclopentylmethyl]-phenoxymethyl}-quinoline

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) NaH / 1.) DMF, 40 min, 2.) RT, 6 h

2: 57 percent / H₂, AcOH / 10percent Pd/C / ethanol / 16 h / 2068.6 Torr

3: 100 percent / BBr₃ / CH₂Cl₂ / 18 h / -78 - 20 °C

4: 95 percent / NaOH / dimethylsulfoxide / 21 h / Ambient temperature

5: 71 percent / NaN₃, NH₄Cl / dimethylformamide / 110 - 120 °C

With sodium hydroxide; sodium azide; hydrogen; boron tribromide; sodium hydride; ammonium chloride; acetic acid; palladium on activated charcoal; In ethanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/jm00172a024

Reference yield:

: 3462-97-3
(4-methoxybenzyl)triphenylphosphonium bromide

: 304024-18-8
2-{4-[2-(1H-Tetrazol-5-ylmethyl)-cyclopentylmethyl]-phenoxymethyl}-quinoline

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) NaH / 1.) DMF, 40 min, 2.) RT, 6 h

2: 57 percent / H₂, AcOH / 10percent Pd/C / ethanol / 16 h / 2068.6 Torr

3: 100 percent / BBr₃ / CH₂Cl₂ / 18 h / -78 - 20 °C

4: 95 percent / NaOH / dimethylsulfoxide / 21 h / Ambient temperature

5: 71 percent / NaN₃, NH₄Cl / dimethylformamide / 110 - 120 °C

With sodium hydroxide; sodium azide; hydrogen; boron tribromide; sodium hydride; ammonium chloride; acetic acid; palladium on activated charcoal; In ethanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/jm00172a024