2,6-Bis[(4R)-4-tert-butyl-2-oxazolin-2YL]pyridine

Base Information

Chemical Name:2,6-Bis[(4R)-4-tert-butyl-2-oxazolin-2YL]pyridine
CAS No.:185346-17-2
Molecular Formula:C₁₉H₂₇N₃O₂
Molecular Weight:329.442
Hs Code.:
DSSTox Substance ID:DTXSID80357347
Nikkaji Number:J1.797.124G
Wikidata:Q72446946
Mol file:185346-17-2.mol

Synonyms:185346-17-2;2,6-BIS[(4R)-4-TERT-BUTYL-2-OXAZOLIN-2YL]PYRIDINE;2,6-Bis((R)-4-(tert-butyl)-4,5-dihydrooxazol-2-yl)pyridine;(4R)-4-tert-butyl-2-[6-[(4R)-4-tert-butyl-4,5-dihydro-1,3-oxazol-2-yl]pyridin-2-yl]-4,5-dihydro-1,3-oxazole;2,6-BIS[(4R)-4-TERT-BUTYL-2-OXAZOLIN-2-YL]PYRIDINE;ZINC00386431;2,6-Bis[(4R)-4-tert-butyloxazolin-2-yl]pyridine;DTXSID80357347;MFCD07368373;AKOS015909280;(4R)-4-tert-butyl-2-[6-[(4R)-4-tert-butyl-4,5-dihydrooxazol-2-yl]-2-pyridyl]-4,5-dihydrooxazole;AS-68279;P20509;2,6-Bis[(4R)-4-tert-butyl-2-oxazoline-2-yl]pyridine;2,6-bis((R)-4-tert-butyl-4,5-dihydrooxazol-2-yl)pyridine;2,6-bis[(4R)-4-tert-butyl-2-oxazolin-2yl]pyridine, AldrichCPR;2,6-BIS[(4R)-4-TERT-BUTYL-4,5-DIHYDRO-1,3-OXAZOL-2-YL]PYRIDINE;2,6-Bis[(4R)-4-tert-butyloxazolin-2-yl]pyridine, 98%, (99% ee)

Suppliers and Price of 2,6-Bis[(4R)-4-tert-butyl-2-oxazolin-2YL]pyridine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Strem Chemicals
2,6-Bis[(4R)-4-tert-butyloxazolin-2-yl]pyridine, 98%, (99% ee) (99% ee)
100mg
$ 102.00

Crysdot
2,6-Bis((R)-4-(tert-butyl)-4,5-dihydrooxazol-2-yl)pyridine 97%
250mg
$ 205.00

Crysdot
2,6-Bis((R)-4-(tert-butyl)-4,5-dihydrooxazol-2-yl)pyridine 97%
100mg
$ 114.00

Crysdot
2,6-Bis((R)-4-(tert-butyl)-4,5-dihydrooxazol-2-yl)pyridine 97%
50mg
$ 64.00

ChemScene
2,6-Bis((R)-4-(tert-butyl)-4,5-dihydrooxazol-2-yl)pyridine >97.0%
100mg
$ 32.00

ChemScene
2,6-Bis((R)-4-(tert-butyl)-4,5-dihydrooxazol-2-yl)pyridine >97.0%
250mg
$ 60.00

ChemScene
2,6-Bis((R)-4-(tert-butyl)-4,5-dihydrooxazol-2-yl)pyridine >97.0%
1g
$ 240.00

Biosynth Carbosynth
2,6-Bis[(4R)-4-tert-butyl-2-oxazolin-2yl]pyridine
250 mg
$ 280.00

Biosynth Carbosynth
2,6-Bis[(4R)-4-tert-butyl-2-oxazolin-2yl]pyridine
1 g
$ 850.00

Biosynth Carbosynth
2,6-Bis[(4R)-4-tert-butyl-2-oxazolin-2yl]pyridine
500 mg
$ 490.00

Total 15 raw suppliers

Chemical Property of 2,6-Bis[(4R)-4-tert-butyl-2-oxazolin-2YL]pyridine

Chemical Property:

Vapor Pressure:1.87E-08mmHg at 25°C
Refractive Index:1.575
Boiling Point:467.1 °C at 760 mmHg
PKA:3.91±0.70(Predicted)
Flash Point:236.3 °C
PSA：56.07000
Density:1.15 g/cm³
LogP:2.33580
Storage Temp.:under inert gas (nitrogen or Argon) at 2-8°C
XLogP3:4.1
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:4
Exact Mass:329.21032711
Heavy Atom Count:24
Complexity:482

Purity/Quality:

95% ^*data from raw suppliers

2,6-Bis[(4R)-4-tert-butyloxazolin-2-yl]pyridine, 98%, (99% ee) (99% ee) ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)(C)C1COC(=N1)C2=NC(=CC=C2)C3=NC(CO3)C(C)(C)C
Isomeric SMILES:CC(C)(C)[C@@H]1COC(=N1)C2=NC(=CC=C2)C3=N[C@@H](CO3)C(C)(C)C

Technology Process of 2,6-Bis[(4R)-4-tert-butyl-2-oxazolin-2YL]pyridine

There total 7 articles about 2,6-Bis[(4R)-4-tert-butyl-2-oxazolin-2YL]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 2893-33-6
pyridine-2,6-dinitrile

: 112245-13-3
(S)-tert-leucinol

: 118949-63-6,185346-17-2
2,6-bis[4'-(S)-(tert-butyl)oxazolin-2'-yl]pyridine

Guidance literature:: With zinc trifluoromethanesulfonate; In toluene; for 48h; Reflux;
DOI:10.1002/anie.201611067

Reference yield: 75.0%

: 3739-94-4
2,6-Pyridinedicarbonyl dichloride

: 112245-13-3
(S)-tert-leucinol

: 118949-63-6,185346-17-2
2,6-bis[4'-(S)-(tert-butyl)oxazolin-2'-yl]pyridine

Guidance literature:: 2,6-Pyridinedicarbonyl dichloride; (S)-tert-leucinol; With potassium hydrogencarbonate; In Isopropyl acetate; at 80 ℃; for 2h;

With boron trifluoride diethyl etherate; at 125 ℃; for 2h; Further stages.;
DOI:10.1021/ol005721h