(S)-2-Benzyloxycarbonylamino-3-(5-bromo-1-oxy-pyridin-2-yl)-propionic acid methyl ester

Base Information

Chemical Name:(S)-2-Benzyloxycarbonylamino-3-(5-bromo-1-oxy-pyridin-2-yl)-propionic acid methyl ester
CAS No.:372520-49-5
Molecular Formula:C₁₇H₁₇BrN₂O₅
Molecular Weight:409.236
Hs Code.:

Synonyms:(S)-2-Benzyloxycarbonylamino-3-(5-bromo-1-oxy-pyridin-2-yl)-propionic acid methyl ester

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Chemical Property of (S)-2-Benzyloxycarbonylamino-3-(5-bromo-1-oxy-pyridin-2-yl)-propionic acid methyl ester

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Technology Process of (S)-2-Benzyloxycarbonylamino-3-(5-bromo-1-oxy-pyridin-2-yl)-propionic acid methyl ester

There total 4 articles about (S)-2-Benzyloxycarbonylamino-3-(5-bromo-1-oxy-pyridin-2-yl)-propionic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (Z)-2-Benzyloxycarbonylamino-3-(5-bromo-1-oxy-pyridin-2-yl)-acrylic acid methyl ester

: 372520-49-5
(S)-2-Benzyloxycarbonylamino-3-(5-bromo-1-oxy-pyridin-2-yl)-propionic acid methyl ester

: (R)-2-Benzyloxycarbonylamino-3-(5-bromo-1-oxy-pyridin-2-yl)-propionic acid methyl ester

Guidance literature:: With hydrogen; (Z,Z)-cycloocta-1,5-diene(R,R-1,2-bis(2,5-diethylphospholanyl)benzene)rhodium(I) tetrafluoroborate; In methanol; at 20 ℃; under 2327.23 Torr; Title compound not separated from byproducts.;
DOI:10.1021/ol016455q

Reference yield:

: 31181-90-5
5-bromo-pyridine-2-carbaldehyde

: 372520-49-5
(S)-2-Benzyloxycarbonylamino-3-(5-bromo-1-oxy-pyridin-2-yl)-propionic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: N,N,N',N'-tetramethylguanidine / tetrahydrofuran / 6 h / 20 °C

2: urea-H₂O₂ complex; TFAA / acetonitrile / 0.5 h / 0 °C

3: H₂ / (R,R)-[Rh(Et-DUPHOS)COD(COD)]BF₄ / methanol / 20 °C / 2327.23 Torr

With hydrogen; urea hydrogen peroxide adduct; trifluoroacetic anhydride; N,N,N',N'-tetramethylguanidine; (Z,Z)-cycloocta-1,5-diene(R,R-1,2-bis(2,5-diethylphospholanyl)benzene)rhodium(I) tetrafluoroborate; In tetrahydrofuran; methanol; acetonitrile;
DOI:10.1021/ol016455q

Reference yield:

: 100945-15-1,88568-95-0
N-(benzyloxycarbonyl)phosphonoglycine trimethyl ester

: 372520-49-5
(S)-2-Benzyloxycarbonylamino-3-(5-bromo-1-oxy-pyridin-2-yl)-propionic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: N,N,N',N'-tetramethylguanidine / tetrahydrofuran / 6 h / 20 °C

2: urea-H₂O₂ complex; TFAA / acetonitrile / 0.5 h / 0 °C

3: H₂ / (R,R)-[Rh(Et-DUPHOS)COD(COD)]BF₄ / methanol / 20 °C / 2327.23 Torr

With hydrogen; urea hydrogen peroxide adduct; trifluoroacetic anhydride; N,N,N',N'-tetramethylguanidine; (Z,Z)-cycloocta-1,5-diene(R,R-1,2-bis(2,5-diethylphospholanyl)benzene)rhodium(I) tetrafluoroborate; In tetrahydrofuran; methanol; acetonitrile;
DOI:10.1021/ol016455q