RP-8-BROMO-BETA-PHENYL-1,N2-ETHENOGUANOSINE 3',5'-CYCLIC MONOPHOSPHOROTHIOATE SODIUM SALT HYDRATE

Base Information

• Chemical Name: RP-8-BROMO-BETA-PHENYL-1,N2-ETHENOGUANOSINE 3',5'-CYCLIC MONOPHOSPHOROTHIOATE SODIUM SALT HYDRATE
• CAS No.: 185246-32-6
• Molecular Formula: C18H15 Br N5 O6 P S . Na
• Molecular Weight: 562.266
• Mol file: 185246-32-6.mol

Synonyms:RP-8-BROMO-BETA-PHENYL-1,N2-ETHENOGUANOSINE 3’,5’-CYCLIC MONOPHOSPHOROTHIOATE SODIUM SALT HYDRATE;Rp-8-Bromo-β-phenyl-1,N2-ethenoguanosine 3μ:5μ-cyclic monophosphorothioate hydrate sodium salt;Rp-8-Br-PET-cGMPS hydrate, Rp-β-Phenyl-1,N2-etheno-8-bromoguanosine 3μ,5μ-cyclic monophosphorothioate hydrate sodium salt

Chemical Property of RP-8-BROMO-BETA-PHENYL-1,N2-ETHENOGUANOSINE 3',5'-CYCLIC MONOPHOSPHOROTHIOATE SODIUM SALT HYDRATE

Chemical Property:

• Melting Point: 240-300 °C(lit.)
• PSA: 190.09000
• LogP: 2.71680
• Storage Temp.: −20°C
• Solubility.: H2O: soluble15mg/mL at ≤60°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

Rp-8-Br-PET-cyclicGMPSSodiumSalt ^*data from reagent suppliers

Safty Information:

• Safety Statements: 22-24/25

MSDS Files:

SDS file from LookChem

Useful:

• Description: Rp-8-bromo-PET-Cyclic GMPS (Rp-8-bromo-PET-cGMPS) is an analog of cyclic GMP (cGMP). It is a cell permeable, competitive, and reversible inhibitor of cGMP-dependent protein kinases (cGKs) that blocks activation of cGKI and cGKII by cGMP (Kis = 35 and 30 nM). It less potently inhibits protein kinase A (Ki = 11 μM) and cGMP-induced activation of cyclic nucleotide-gated channels (IC50 = 25 μM). In the absence of cGMP stimulation, Rp-8-bromo-PET-cGMPS can act as a partial agonist of cGKI (Ki = 1 μM). Rp-8-bromo-PET-cGMPS is resistant to hydrolysis by phosphodiesterase 11.