2-[(4-chlorobenzyl)sulfanyl]-4,6-dimethylpyridine-3-carbonitrile

Base Information

• Chemical Name: 2-[(4-chlorobenzyl)sulfanyl]-4,6-dimethylpyridine-3-carbonitrile
• CAS No.: 312758-03-5
• Molecular Formula: C₁₅H₁₃ClN₂S
• Molecular Weight: 288.801
• Mol file: 312758-03-5.mol

Synonyms:2-[(4-chlorobenzyl)sulfanyl]-4,6-dimethylpyridine-3-carbonitrile

Chemical Property of 2-[(4-chlorobenzyl)sulfanyl]-4,6-dimethylpyridine-3-carbonitrile

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of 2-[(4-chlorobenzyl)sulfanyl]-4,6-dimethylpyridine-3-carbonitrile

There total 2 articles about 2-[(4-chlorobenzyl)sulfanyl]-4,6-dimethylpyridine-3-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

4,6-Dimethyl-2-thioxo-1,2-dihydro-pyridine-3-carbonitrile (54585-47-6) → 2-[(4-chlorobenzyl)sulfanyl]-4,6-dimethylpyridine-3-carbonitrile (312758-03-5)

Guidance literature:

4,6-Dimethyl-2-thioxo-1,2-dihydro-pyridine-3-carbonitrile; With potassium hydroxide; In methanol; Heating;

4-chlorobenzyl halide; In methanol; for 0.5h; Reflux;

DOI:10.1007/s11172-008-0290-6

Reference yield: 74.0%

4,6-Dimethyl-2-thioxo-1,2-dihydro-pyridine-3-carbonitrile (54585-47-6) + 4-chlorobenzyl bromide (622-95-7) → 2-[(4-chlorobenzyl)sulfanyl]-4,6-dimethylpyridine-3-carbonitrile (312758-03-5)

Guidance literature:

With potassium hydroxide; In water; N,N-dimethyl-formamide; for 4h;

DOI:10.1134/S1070428016010061

Reference yield: 75.0%

2-[(4-chlorobenzyl)sulfanyl]-4,6-dimethylpyridine-3-carbonitrile (312758-03-5) → 2-{[(4-chlorophenyl)methyl]sulfonyl}-3-cyano-4,6-dimethylpyridine (442152-73-0)

Guidance literature:

With potassium permanganate; acetic acid; at 20 - 25 ℃;

DOI:10.1007/s11172-008-0290-6

upstream raw materials:

4,6-Dimethyl-2-thioxo-1,2-dihydro-pyridine-3-carbonitrile

4-chlorobenzyl bromide

Downstream raw materials:

2-[(4-chlorophenyl)methyl]sulfinyl-3-cyano-4,6-dimethylpyridine

2-{[(4-chlorophenyl)methyl]sulfonyl}-3-cyano-4,6-dimethylpyridine